The Delusions & Reality of Hormone Cycling

Are you delusional or realistic about your physique goals?

If I were to ask you point blank what your body fat is what would you tell me face to face?

If I were to show you a picture of someone else's body that is very similar to yours, would you acknowledge it or be in denial?

If you and your significant other see a man walk by twice the musculature that you are and much leaner would you credit him or tell yourself that if you took the same stuff (drugs) he took, you would appear the same?

These are all questions and scenario's that I have witnessed, and reminds me that some people cannot grasp reality. 

Let's start from the beginning…

When you first begin weight training, you are usually clueless and unaware of proper nutrition,rest, training and all the key variables involved in getting results. For the fresh beginner, results will manifest regardless, simply due to the "foreign" stress that is happening to your fresh muscle tissue. Muscle growth, increase in metabolic rate and a better sense of well-being will inevitably happen…..AT FIRST. Once this grace period comes to a plateau (usually a few months) you will need to further educate yourself about proper nutrition and more sound training routines to keep the results soaring.  

Let's investigate a typical hypothetical scenario –

Although everybody gets results in the very early stages of weight training, some people respond ABNORMALLY well to lifting weights and will leave their training partners in the dust! So if both trainees started weight training at the same time, but one surpassed the other by a huge margin, it is very apparent that genetics are crucial in muscle hypertrophy and favorable body composition. The training partners will both accrue more knowledge in regards to nutrition, supplementation, and different training techniques but the genetic superior will always stay way ahead.  As time passes the thought of hormonal assistance is becoming extremely tempting to the genetic inferior.  In fact, he begins his first cycle in hopes to surpass his training partner. He begins to put some weight on (water–>via–>glycogen retention), his strength begins to increase, muscles appear fuller (more 3-dimensional looking) but he still does not look like his training partner?

I mean, he has put on 15-20 lbs. in 4 weeks, and has gotten stronger, but he still is not as impressive as his damn training partner! 

This scenario is so harsh and disheartening for most people to accept that it literally drives them insane. If they don't accept the fact that some peoples genetic makeup responds better to muscle stimuli, food, drugs and all other pertinent aspects of muscle growth- they begin to make assumptions for their short-comings. Perhaps thinking their superior partners are taking some special product behind their backs, taking huge amounts of hormones or all of the above. Let's say that the genetic superior decided to dabble in hormonal assistance, most likely due to other experienced people noticing his potential, telling him how well he'd do in Bodybuilding and what not. 

This is when the genetic elite trainee EXPLODES! His already lean and muscular physique gets even more profound with big & round muscles and low body fat. 

As you can see from this common scenario, it will be obvious right from the beginning who is predisposition to be a lean & muscular elitist among people with mediocre genetics. 

So what can you do about this painful, yet rude awakening fact of life?

Well, first off get your training and nutrition down as best as you can before even CONSIDERING hormonal assistance. How many times have you seen younger "newbies" choose a harsh methylated, designer hormone before considering a high quality protein powder, let alone even looking as if they lift weights to begin with? People want to take short-cuts and assume that hormones are the missing link to them looking like a Greek God. 

Once you stress all variables at your disposal then you may need to turn to hormones for breaking through new grounds. Once you commit to going to the "dark side" of hormonal cycling understand that you will get results, but DO NOT get irate when you don't turn into Mr.Olympia afterwards, 

It is truly sad when someone who fails to grasp reality will cycle steroids and gain a respectable amount of muscle (8-14 lbs.), gains some strength, loses some body fat, yet are pissed off that they did not achieve more? 

For the newbie hormone user or experienced user, you must still continue on with your diligent eating and training regimen that you SHOULD HAVE been doing in the first place. To truly maximize your supra-physiological hormone levels, you must feed the muscle high quality protein, essential fats, and complex carbs every day. Just because you have an athletic friend from Nigeria who can eat candy, potato chips and fast food all day and go to the gym for a half -ass workout and look better than you does NOT mean that you shouldn't do everything in your power to make the most of what you got.

Let's now make a "Pre-Cycle Checklist" for variables that MUST be addressed before committing to a hormone cycle

The Pre-Cycle Checklist – 

1.) I have stressed all avenues of nutrition and found out what suits my body best.

2.) I have stressed all facets of training and found out what suits my body best.

3.) I have been training diligently for more than 6 months while eating and training consistently.

4.) I understand that genetics play an integral role in nutrition response, training response and hormone response.

5.) I understand that you CANNOT continue gaining 10-15 lbs. each and every cycle.

6.) I understand that there is a "diminishing returns" effect when using higher dosages of hormones and side   effects become prominent.

7.) I understand that to improve upon each cycle I must increase a variable to continue gaining – increase calories or increase weight on lifts or increase dosage of hormone or all of the above.

8.) I understand that SAYING I eat 5000 calories a day is much different than LITERALLY EATING 5000 calories a day.

9.) I understand that SAYING I am 8-9% body fat is much different than LITERALLY being 8-9% body fat with ALL abs fully visible and have very thin skin all over.

10.) I understand and acknowledge all of the above.

If you can understand & oblige to this list, then you are realistic enough and mature enough to engage into hormonal assistance. You must segregate yourself from false perceptions and accept reality. Please do not become discouraged from the information given and use it to your benefit and seek out your underlying potential, just be a realist about it.

I personally have witnessed several competitive Bodybuilders' with average genetics annihilate genetically gifted or "elite" athletes due to impeccable work ethic, adherence to perfect nutrition, and giving everything they had to achieve the end result they sought after. I have noticed a lot of the time, the genetic elite athletes understand that they can do the bare minimum and look better than 95% of everyone else. This awareness makes them LAZY. Can you imagine if that genetically gifted person had the drive, will power, and persistence as the average athlete that is a work horse? It would be a sight to behold. 

I hope everything discussed in this article will "sink in" and let each and every one of you acknowledge the importance of all variables involved in this muscle-building equation. Leave no stone un-turned, and give it everything you got, because for most humans……..building high-quality muscle isn't easy.

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Pharmacokinetics and Pharmacodynamics of Steroid Esters

Pharmacokinetics and Pharmacodynamics of Steroid Esters in Oil Vehicle:
Effects of Ester, Injection Site, and Injection Volume

Variations in side-chain ester chemistry are important in the pharmacokinetics of androgen esters in oil vehicle. In humans, the very short propionate (three-carbon aliphatic) ester of testosterone has distinctly shorter duration of action than esters with longer (seven- or eight-carbon) side-chains. More subtle changes in side-chain ester structure have proven ineffective in altering human clinical pharmacokinetics, because substitution of a linear aliphatic side-chain of seven carbons (enanthate) with either a saturated, cyclized, seven-carbon aliphatic chain (cyclohexanecarboxylate) or a linear, aliphatic, eight-carbon chain (cypionate) resulted in virtually unchanged kinetics. (2, 4-6, 12, 15)

Testosterone enanthate (TE) or testosterone cypionate (TC), injected intramuscularly, are the most commonly used androgen preparations with terminal half-lifes of 7-12 days. Pharmacokinetic studies indicate that the major limitations of TE and TC include relatively high peak levels and limited duration of T levels within the normal range (approximately 2 weeks), following an injection. Disadvantages of TE and TC highlighted the need for long-acting preparations of T with more stable delivery kinetics. Testosterone undecanoate (TU; 17-hydroxy-4-androsten-3-one undecanoate) is an unsaturated, aliphatic, fatty acid ester of testosterone (T) in 17β-position. In ampules containing 250 mg of the ester in 2 ml of tea seed oil in administration of 500 or 1,000 mg shows a terminal elimination half-life of 18-23 days. (4, 10, 15, 17)

Testosterone
Testosterone

Testosterone Enanthate
Testosterone Enanthate

Testosterone Cypionate
Testosterone Cypionate

Testosterone Undecanoate
Testosterone Undecanoate

Wider variation in ester side-chain chemistry to include greater chain length and/or aromatic ring structures is a more effective determinant of ester pharmacokinetics. Nandrolone hexoxyphenylpropionate ester has far better depot properties, with a prolonged and retarded release profile, compared with the decanoate (aliphatic chain with 10 carbons). Another study indicates the decanoate (aliphatic chain with 10 carbons) ester has better depot properties than a nine-carbon chain including an aromatic ring. Because the vehicle (arachis oil) was unchanged during this latter study and because of the experimental observation that the oil vehicle influences local reaction to the oil injection, as well as androgen ester pharmacology, these conclusions may be extrapolated to other vegetable oil injection vehicles only with caution. (2, 7, 13, 14, 16)

In addition to the chemistry of the side-chain ester, both injection site and volume can systematically influence blood levels after intramuscular injection of esters in an oil vehicle formulation. Injection site may be important because of differences in tissue composition and blood flow. Intramuscular oil-based injections may more accurately be termed intermuscular or intralipomatous. The former reflects the tendency of oil vehicle to distribute along intermuscular fascial planes, whereas the latter depends upon the amount of fat at the injection site (including systematic gender differences) together with needle geometry and anatomy of the injection depot. Intralipomatous deposition of injections with a larger vehicle volume may explain the slower release kinetics of nandrolone decanoate in the gluteal region, as well as the differences from the deltoid site, which has a lower fat content. (1, 13)

Nandrolone

Nandrolone

Nandrolone Decanoate

Nandrolone Decanoate

Nandrolone Phenpropionate (NPP)

Nandrolone Phenpropionate (NPP)

Nandrolone P-Hexoxyphenylpropionate

Nandrolone P-Hexoxyphenylpropionate

There is a rapid and dose-proportional increase in nandrolone serum levels across a dose range after a single intramuscular injection of 50–150 mg nandrolone decanoate in healthy young men with peak serum levels of nandrolone reached 2–3 d after injection. Subsequently, nandrolone levels decreased, but were still measurable 32 d after dosing in approximately half the subjects in the 50-mg group and in all subjects in the 100- and 150-mg groups. The half-life ranged from 7.1 days – 11.8 days. In addition, urinary metabolites 19-NA and/or 19-NE were detectable for up to 6 months after the 100 and 150 mg injection in a significant proportion of subjects. (2)

 Nandrolone Profile

Mean serum concentration profiles for nandrolone after single gluteal muscle injection in 1 ml arachis oil of 50, 100, or 150 mg nandrolone decanoate in healthy men.

Nandrolone displays so-called flip-flop pharmacokinetics, which means that the ascending phase of the curve represents the disposition of nandrolone and the descending part of the curve represents the rate-limiting process of release of nandrolone decanoate from the muscle into the general circulation. The half-life in the descending phase of the curve is an estimate of the absorption half-life rather than the elimination half-life. (2)

In the following study, 23 healthy men were randomized into four groups receiving a single dose of 100 mg nandrolone esters: nandrolone phenylpropionate in 4 ml arachis oil injected into the gluteal muscle (group 1), nandrolone decanoate in 4 ml arachis oil injected into the gluteal muscle (group 2), nandrolone decanoate in 1 ml arachis oil injected into the gluteal muscle (group 3), or nandrolone decanoate in 1 ml arachis oil injected into the deltoid muscle (group 4). Absolute bioavailability was higher after single-dose injection of 100 mg nandrolone decanoate in 1 ml arachis oil into the gluteal muscle (73%) than in the other three groups (53–56%). (8)

TIME COURSE OF PLASMA NANDROLONE ESTER CONCENTRATIONS

Nandrolone Concentrations

Time course of plasma nandrolone concentrations in 23 healthy men over 32 days after intramuscular injection of 100 mg of nandrolone phenylpropionate in 4 ml of arachis oil vehicle into the gluteal muscle (group 1) () or injection of 100 mg of nandrolone decanoate into the gluteal muscle in 4 ml of arachis oil vehicle (group 2) (?), into the gluteal muscle in 1 ml of arachis oil vehicle (group 3) (•) or into the deltoid muscle in 1 ml of arachis oil vehicle (group 4) (?). Results are expressed as mean and S.E.M., unless the S.E. is smaller than symbol. (8)

Corresponding to the patterns of blood concentrations, pharmacodynamic indices reflecting androgen-induced inhibition of pituitary-testicular function, namely blood testosterone and inhibin concentrations, are also systematically influenced by these factors. Testosterone and inhibin concentrations represent effective markers of endogenous pituitary gonadotropin (LH and FSH, respectively) secretion. This reflects the physiological fact that pituitary LH acts exclusively upon testicular Leydig cells, due to their unique expression of cell surface membrane LH receptors. In healthy men, virtually all circulating testosterone originates from Leydig cells, with an absolute requirement for trophic influence from LH derived from the bloodstream. Similarly, pituitary FSH acts exclusively upon testicular Sertoli cells, which uniquely express FSH receptors on their cell surface membranes, and virtually all circulating immunoreactive inhibin originates from the gonads. As a result, blood levels of these two hormones are useful integrated bioassay indicators of endogenous pituitary gonadotropin secretion, as reflected by the testicular hormonal response to ambient blood LH and FSH levels. These two pharmacodynamic indices show physiologically meaningful distinctions between the esters and the effects of injection site and volume. (8, 9, 11)

TIME COURSE OF PLASMA TESTOSTERONE CONCENTRATIONS AFTER I.M. INJECTION OF 100 MG OF NANDROLONE ESTER

Testosterone Concentrations

Time course of plasma testosterone concentrations in 23 healthy men over 32 days after intramuscular injection of 100 mg of nandrolone phenylpropionate in 4 ml of arachis oil vehicle into the gluteal muscle (group 1) () or injection of 100 mg of nandrolone decanoate into the gluteal muscle in 4 ml of arachis oil vehicle (group 2) (?), into the gluteal muscle in 1 ml of arachis oil vehicle (group 3) (•) or into the deltoid muscle in 1 ml of arachis oil vehicle (group 4) (?). Results expressed as mean and S.E.M., unless the S.E. is smaller than the symbol. (8)

The pharmacodynamic variability in plasma testosterone and inhibin concentrations is accounted for by the variability between esters and the site and volume of injection of the nandrolone injections. The overall kinetics of suppression of testosterone is dominated by the slow negative feedback system, rather than the much faster metabolic clearance of testosterone. This negative feedback is mediated via inhibition of pulsatile gonadotropin-releasing hormone secretion from hypothalamic neurons into the pituitary portal system and then pituitary LH secretion from gonadotropes. This is in stark contrast to a highly potent and specific gonadotropin-releasing hormone antagonist that causes immediate cessation of gonadotropin-releasing hormone action leading to castrate testosterone concentrations within 12 hr, compared with 5 to 10 days with AAS administration. After a single 100 mg injection of NPP, recovery takes 10+ days. After ND, recovery takes 15+ days. It is important to note these are single administrations of 100 mg. HPTA recovery with repeated doses of 200+ mg is long!!!! (3, 8)

Administration of androgens such as testosterone and 19-nor-testosterone has been most frequently via depot intramuscular injections of steroid esters dissolved in a vegetable oil vehicle. Intramuscular injections provide sustained androgen release into the circulation and remain the mainstay of androgen replacement therapy. Experimental studies suggest that absorption rates are predicted by the oil/water partition coefficients (or hydrophobicity) and that the oil vehicle is absorbed more slowly than the androgen ester, with gradual release into the extracellular fluid, where esters are rapidly hydrolyzed to liberate biologically active steroid. As the above shows, other factors influence steroid appearance in the bloodstream that include the chemistry of the side-chain ester (hydrophobicity, steric hindrance of hydrolysis, and solubility), as well as injection factors (technique, depth, site, volume, Ph, and osmolarity of the solution).

 1.                  Al-Hindawi MK, James KC, Nicholls PJ. Influence of solvent on the availability of testosterone propionate from oily, intramuscular injections in the rat. J Pharm Pharmacol 1987;39(2):90-5. http://www.ncbi.nlm.nih.gov/pubmed/2882010

2.                  Bagchus WM, Smeets JMW, Verheul HAM, De Jager-Van Der Veen SM, Port A, Geurts TBP. Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate: Analysis of Serum and Urine Samples in Healthy Men. J Clin Endocrinol Metab 2005;90(5):2624-30. http://jcem.endojournals.org/cgi/content/full/90/5/2624

3.                  Behre HM, Klein B, Steinmeyer E, McGregor GP, Voigt K, Nieschlag E. Effective suppression of luteinizing hormone and testosterone by single doses of the new gonadotropin-releasing hormone antagonist cetrorelix (SB-75) in normal men. J Clin Endocrinol Metab 1992;75(2):393-8. http://www.ncbi.nlm.nih.gov/pubmed/1639941

4.                  Behre HM, Nieschlag E. Testosterone buciclate (20 Aet-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long-acting androgen ester. J Clin Endocrinol Metab 1992;75(5):1204-10. http://www.ncbi.nlm.nih.gov/pubmed/1430080

5.                  Belkien L, Schurmeyer T, Hano R, Gunnarsson PO, Nieschlag E. Pharmacokinetics of 19-nortestosterone esters in normal men. J Steroid Biochem 1985;22(5):623-9. http://www.ncbi.nlm.nih.gov/pubmed/4010287

6.                  Fujioka M, Shinohara Y, Baba S, Irie M, Inoue K. Pharmacokinetic Properties of Testosterone Propionate in Normal Men. J Clin Endocrinol Metab 1986;63(6):1361-4. http://www.ncbi.nlm.nih.gov/pubmed/3782423

7.                  Khankhanian NK, Hammers YA, Kowalski P. Exuberant local tissue reaction to intramuscular injection of nandrolone decanoate (Deca-Durabolin)–a steroid compound in a sesame seed oil base–mimicking soft tissue malignant tumors: a case report and review of the literature. Mil Med 1992;157(12):670-4. http://www.ncbi.nlm.nih.gov/pubmed/1470383

8.                  Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ. Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume. J Pharmacol Exp Ther 1997;281(1):93-102. http://jpet.aspetjournals.org/content/281/1/93.full

9.                  Nieschlag E, Cuppers HJ, Wiegelmann W, Wickings EJ. Bioavailability and LH-suppressing effect of different testosterone preparations in normal and hypogonadal men. Horm Res 1976;7(3):138-45. http://www.ncbi.nlm.nih.gov/pubmed/1002121

10.              Schubert M, Minnemann T, Hubler D, et al. Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism. J Clin Endocrinol Metab 2004;89(11):5429-34. http://www.ncbi.nlm.nih.gov/pubmed/15531493

11.              Schulte-Beerbuhl M, Nieschlag E. Comparison of testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of testosterone enanthate of testosterone cypionate. Fertil Steril 1980;33(2):201-3. http://www.ncbi.nlm.nih.gov/pubmed/7353699

12.              Schurmeyer T, Nieschlag E. Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men. Int J Androl 1984;7(3):181-7. http://www.ncbi.nlm.nih.gov/pubmed/6434435

13.              Tanaka T, Kobayashi H, Okumura K, Muranishi S, Sezaki H. Intramuscular absorption of drugs from oily solutions in the rat. Chem Pharm Bull (Tokyo) 1974;22(6):1275-84. http://www.ncbi.nlm.nih.gov/pubmed/4417722

14.              van der Vies J. Implications of basic pharmacology in the therapy with esters of nandrolone. Acta Endocrinol Suppl (Copenh) 1985;271:38-44. http://www.ncbi.nlm.nih.gov/pubmed/3865480

15.              Weinbauer GF, Partsch C-J, Zitzmann M, Schlatt S, Nieschlag E. Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularis. J Androl 2003;24(5):765-74. http://www.andrologyjournal.org/cgi/content/full/24/5/765

16.              Wijnand HP, Bosch AM, Donker CW. Pharmacokinetic parameters of nandrolone (19-nortestosterone) after intramuscular administration of nandrolone decanoate (Deca-Durabolin) to healthy volunteers. Acta Endocrinol Suppl (Copenh) 1985;271:19-30. http://www.ncbi.nlm.nih.gov/pubmed/3865478

17.              Zhang GY, Gu YQ, Wang XH, Cui YG, Bremner WJ. A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men. J Androl 1998;19(6):761-8. http://www.ncbi.nlm.nih.gov/pubmed/9876028

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Leading the Steroid Revolution

Leading the Steroid Revolution

What makes a steroid revolution?

As a general rule, if you are 100% better at something, you are evolutionary. If you are 1,000% better, you are revolutionary.

Since the mid 90’s, we’ve seen a number of companies bring evolutionary products to the market, including Biotest, Ergopharm, Molecular Nutrition and many others along the way. However, nothing has quite been revolutionary, nor have we seen much development since the major “pro-hormone” ban in 2004.

Technologically our new delivery system is going to be about 10x better than our previous version of Liqua-Vade, making the AndroSeries easily 1,000% better than its predecessors or the nearest competition. This technology allows the specifically chosen natural steroids to be delivered orally at a rate of 75-85% — with biological effects calculated down to the milligram – so we can predict the exact effects relative to actual injectable steroids.

But the fuel behind the fire is more than just technology – there is ideology.


Steroids for the Heart, Mind & Muscle

Our definition of a “steroid” is a hormone that is naturally produced by the body. We aren’t talking about synthetic chemically modified steroids – like the toxic methylated steroids that are almost single handedly responsible for creating the negative stigma around the word “steroid”. We are talking about natural steroids, and don’t forget, testosterone is a steroid.

Now forget the media’s spin of the word “steroid” and consider ours –

Steroids for the Heart, Mind and Muscle

The phrase could be taken literally if you like. However, our definition is more abstract. We chose to define it with timeless human attributes –

Heart = Honorable, warm and spirited.
Mind = Logical, purposeful and dignified
Muscle = Rugged, independent and powerful

To us, this is the true definition of a Testosterone fueled man – which anyone can willfully become.

But let me make something very clear.

We aren’t saying that steroids will give you these qualities. No, that would be obscene. We only hope that the statement will inspire you to fulfill these qualities – as a moral reminder, each time you face a challenge, opportunity or reward.


Steroids saving America

Vice President Joe Biden testifying before congress on steroids, a qyote from the movie Bigger, Stronger, Faster: “There is something un-American about this.”  What America has this man been residing in?


Senator Joe Biden once said steroids are “un-American”.

What America was he talking about?

Steroids are the sovereign juice that fueled the formation of America. If it wasn’t for the testosterone pulsing through the veins of the Patriots, the American Revolution never would have happened. It’s testosterone that fuels the hard working blue collar American – it fuels us during a time of recession and difficult times – and fuels us to get back up again.

If anything, this nation is currently a little short on steroids. We are in a time where testosterone levels have continued to decline each and every decade — while depression, sexual impotence and obesity related diseases continue to increase.

Are steroids going to save us?

They already are.

Obesity, diabetes, impotence, depression, and muscle wasting diseases — all being treated with steroids. (1-4)

Perhaps the slogan “Steroids for the Heart, Mind and Muscle” was a literal statement after all – Or perhaps it’s something bigger – Perhaps it’s the beginning of a steroid revolution.

References –

1. Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity.
Tishova Y, et al.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):1047-51.

2. A new oral testosterone undecanoate formulation.
Köhn FM, et al
World J Urol. 2003 Nov;21(5):311-5. Epub 2003 Oct 25

3. Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial.
Sardar P, et al.
HIV Clin Trials. 2010 Jul-Aug;11(4):220-9

4. Comparison of the effects of high dose testosterone and 19-nortestosterone to a replacement dose of testosterone on strength and body composition in normal men.
Friedl KE, et al.
J Steroid Biochem Mol Biol. 1991;40(4-6):607-12.

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