Methyldrostanolone (Superdrol)

Diagram of molecule

Chemical Name(s):

2a,17a-dimethyl-5a-androst-3-one-17b-ol
2a,17a-dimethyl-etiocholan-3-one-17b-ol
Chemical Formula: C21H34O2
Molecular Weight: 318
CAS: NA
Q Qatio: 20
Anabolic #: 400
Androgenic #: 20
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: High
Half Life: ~8 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
10-30mg/day standalone
5-10mg/day when stacked
Average Cycle Length: 2-4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Methyldrostanolone is a C-17 alpha alkylated steroid, originally developed by the American pharmaceutical company Syntex. This steroid is already active and does not require conversion. Methyldrostanolone is the 17aa version of the injectable steroid drostanolone (Masteron). This extra methylation makes this steroid about 3-4x more anabolic than Masteron, and slightly more anabolic than oxandrolone (Anavar). Due to the dimethylation, the toxicity of methyldrostanolone is greater than most other oral steroids. There have been many reported cases of heptatoxicity with this compound. (1-3)

Despite the fact that methyldrostanolone is a DHT derivative and cannot convert to estrogen, some users have still reported gyno like symptoms during or after a cycle. This effect is likely related to the strong SHBG binding effect and increase in freely circulating estrogen (and testosterone) from SHBG. Gyno symptoms may also be related to the fact that methldrostanolone lacks a strong DHT metabolite to antagonize the effects of estrogen (while also having a relatively low intrinsic androgenic value).

Having a fairly low androgenic value will mean that methyldrostanolone will be light on the hairline for most men. However those susceptible to male pattern baldness may still noticed accelerated hair loss during a cycle.

Because of the di-methylation, methlydrostanolone is considerably more resistant to breakdown, thus more potent per mg than most other steroids. However this makes it more liver toxic than other single methylated 17aa orals. Negative effects on the liver generally manifest as a condition known as reversible cholestasis. This is essentially a slowing or complete blockage of bile acids from the liver. Immediate signs of compromised liver function included reduced appetite and general sickness, which will soon be accompanied by yellowing of the eyes (jaundice), excessive itchiness and very dark urine. If these effects are noticed, methyldrostanolone should be discontinued immediately.

Because the effects on the liver it is very important to use a liver protecting supplement during any methyldrostanolone cycle. If not using a supplement to protect your liver, methyldrostanolone should never be used any longer than 2 weeks, with a maximum cycle length of 4 weeks with liver protection.

Other reversible side effects from methyldrostanolone may include increased blood pressure, reduced HDL cholesterol and lower back pumps.

Results wise, users should expect extreme strength increases and weight gain in a relatively short 2-4 week period. Weight gain upwards of 20lbs in 4 weeks is not unheard of with this incredibly potent compound. Although subcutaneous water gain would be minimal, intramuscular water retention should be expected. This is due to inhibition of 11b-hydroxylase and build-up of mineralcorticoids which encourage salt and water retention within the muscles. The most obvious physical effects will be improved vascularity, aggressive muscular pumps, and oily skin.

While methyldrostanolone can stack well with most other steroids, it should never be stacked with another methylated (17aa) steroid.

Common Clones:


Oxodrol 12 by IDS
Superdrol by Anabolic Xtreme
M-Drol by Competitive Edge Labs (CEL)
SD-1 by Performance Design
Methyl VOL by Engineered Sports Technology (EST)
Revenge SDX by Bioscience Technologies
S-Drol by Nutracoastal
E-Pol by Purus Labs
MethaDROL by IForce
Straight-DROL by Black China Labs
MethylDX3 by Physical Enhancing Industries
Oxevol (same as Dianevol) by Evolution Labs
Beastdrol by Mrsupps



Related Discussion

The Official Methyldrostanolone (Superdrol) Thread
Posted by Eric

References

Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol.

Beata Jasiurkowski MD, et al.
The American Journal of Gastroenterology (2006) 101, 2659-2662;

Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol (Methasteron): A Case Report and Literature Review
John Nasr and Jawad Ahmad
Digestive Diseases and Sciences

Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases”
Neeral L. et al.
Clinical Gastroenterology and Hepatology, Volume 6, Issue 2, February 2008, Pages 255-258

Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes”
Julie Gauthier, Danielle Goudreault, Donald Poirier and Christiane Ayotte
Steroids; Volume 74, Issue 3, March 2009, Pages 306-314

Dimethazine

Diagram of molecule

Chemical Name(s):
17beta-hydroxy 2alpha,17alpha-dimethyl 5alpha-androstan 3-one azine
Chemical Formula: C42H68N2O2
Molecular Weight: 632
CAS: NA
Q Qatio: 2.2
Anabolic #: 210
Androgenic #: 95
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
20-40mg/day standalone
10-20mg/day when stacked
Average Cycle Length: 2-4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Dimethazine is actually two steroid molecules bound together by a nitrogen atom. Upon ingestion, stomach acid separates the two steroid molecules that closely resemble methyldrostanolone (Superdrol).

Although dimethazine appears very similar to methyldrostanolone, the presence of a nitrogen at the 3rd position appears to increase its androgenic potency relative to its anabolic potency (210/95 compared to 400/20 for methyldrostanolone). Therefore, dimethazine could be considered a slightly weaker form of methyldrostanolone, but perhaps less likely to cause gyno related issues because of its higher relative androgenic value (and ability to antagonize estrogenic effects).

Otherwise, all side-effects and benefits could be considered relatively the same as methyldrostanolone. Liver toxicity and its associated side-effects of general sickness should still be expected, especially if the liver becomes compromised. Using a liver protecting supplement prior to and during a cycle of Dimethazine would be very important.

The quick gains in size and strength will likely be accompanied by increases in intense back pumps, high blood pressure, shortness of breath and oily skin. Vascularity would also be expected to improve with this compound due to the increase in extra-cellar water and possible decrease in subcutaneous water weight.

Because this compound is a 17aa oral, it is not recommended to be stacked with other 17aa oral steroids.

Common Clones:

Dymethazine by IForce


Related Discussion

The Official Dimethazine Thread
Posted by Eric

References

“Oral administration of an anabolic-androgenic steroid dimethazine increases the growth and food conversion efficiency and brings changes in molecular growth responses of carp (Cyprinus carpio) tissues”

LONE K. P. (1) ; MATTY A. J. ;
Nutrition reports international

“Contribution to the study of the proteoanabolic effects of dimethazine. (Clinical research)”
CEI C, ANSELMI G.
Gazz Med Ital. 1963 Feb;122:57-61

“A new steroid having proteo-anabolic action: dimethazine.”
DE RUGGIERI P, MATSCHER R, GANDOLFI C, CHIARAMONTI D, LUPO C, PIETRA E, CAVALLI R.Arch Sci Biol (Bologna). 1963 Jan-Mar;47:1-19.

Desoxymethyltestosterone (Pheraplex, DMT, Madol)

Diagram of molecule

Chemical Name(s):
17a-methyl-etioallocholan-2-ene-17b-ol
17a-methyl-5a-androst-2-ene-17b-ol
Chemical Formula: C20H32O
Molecular Weight: 288
CAS: NA
Q Qatio: 6.5
Anabolic #: 1200
Androgenic #: 187
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~9 hours
Legal Status (US): Listed as a controlled substance
Average Dose:
40-60mg/day standalone
10-30mg/day when stacked
Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Desoxymethyltestosterone (DMT) is a 17aa steroid with equal toxicity as other 17aa oral steroids. While nearly all anabolic steroid molecules have a 3-keto group, Desoxymethyltestosterone lacks it, and has a 2-ene structure. This compound is readily active and does not require conversion.

DMT does not aromatize, nor does it appear to have any progestational activity, yet some users still experience gyno symptoms and bloat from this compound. This is likely related to the lack of androgenic potency from this compound (to antagonize the effect of estrogen). DMT may also contribute to gyno by displacing estrogen (and testosterone) from SHBG. It has also been proposed that DMT can inhibit 11b-hydroxylase and thus increase intracellular sodium and water retention by building up mineralcorticoid levels.

Depending on where you look, DMT has been reported to be 2-12 times more anabolic and 0.4-2 times as androgenic as methyltestosterone. It has been proposed that DMT is a naturally occurring substance because it has an almost identical structure to delta 2-androstenol, a naturally occurring pheromone in mammals. However, being a 17aa steroid hormone makes it synthetically altered and not naturally occurring. Either way, it is now a controlled substance in the United States.

Users should expect significant strength increases, weight gain, and bloat. Weight gains upwards of 20lbs in 4-6 weeks are not unheard of with this compound. The most obvious physical side effects will be strong muscular pumps, shortness of breath, high blood pressure, oily skin, and bloating. If users wanted to minimize toxic effect on the liver or other side effects, DMT could be used at doses as low as 10mg/day for a decent effect.

Being that this compound is methylated, it should not be stacked with other methylated compounds. Having moderately low androgenic activity, DMT may negatively affect the libido and erectile function. This side effect could be offset by stacking DMT with testosterone or one of its non-aromatizing metabolites to preserve DHT levels.

Common Clones:

P-Plex by Competitive Edge Labs (CEL)
Phera-Plex by Anabolic Xtreme
Nasty Mass by Purus Labs
Phera-VOL by Engineered Sports Technology (EST)
PheraFLEX by IForce
D-Stianozol by Nutracoastal
Pheradrol by PH Design
P-Max by Growth Labs
Phera-MAX by Generic Labs
Phera-BOL by Juggernaut Nutrition
Phera-Mass by Kilo Sports
Straight Phlexed by Black China Labs

Related Discussion

The Official Desoxymethyltestosterone (Pheraplex, DMT, Madol) Thread
Posted by Eric

References

“Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping”

P. Diel, A. Friedel, H. Geyer, M. Kamber, U. Laudenbach-Leschowsky, W. Schänzer, M.
Thevis, G. Vollmer and O. Zierau
Toxicology Letters; Volume 169, Issue 1, 28 February 2007, Pages 64-71

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