Formestane

Diagram of molecule

Chemical Name(s):

4-Hydroxyandrost-4-ene-3, 17-dione
4-hydroxy-4-androstene-3,17-dione
4-Hydroxyandrostenedione
Chemical Formula: C19H26O3
Molecular Weight: 302
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: 2-3 hours oral, Transdermal: Varies by matrix
Legal Status (US): Not listed as a controlled substance
Average Dose:
Aromatase inhibition
100-200mg/day (transdermal)
150-250mg/day (oral)

Anabolic effects
800-1000mg/day (oral)

Average Cycle Length: 4-8 weeks

Stimulator
Inhibitor

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-4
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-1

0
1
2
3
4
5

Muscle Gain

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-5
-4
-3
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-1

0
1
2
3
4
5

Strength Gain

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-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Formestane is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

Formestane was originally used as an injectable for breast cancer patients, but due to its possible androgenic effects it has largely been replaced by non-steroidial AIs in the medical community. Most of its use is now is limited to the bodybuilding community since it is available as a legal dietary supplement for reducing estrogen and increasing testosterone production.

Although formestane can effectively reduce estrogen through oral consumption, its low oral bioavailability has lead to the development of several transdermal based products (which appear to offer higher efficacy at a lower dose).

Relative to 6-oxo and ATD, Formestane is a more potent aromatase inhibitor, which appears to effectively reduce natural estrogen levels by as much as 50% within several days (while higher doses may further suppress estrogen). Because of formestanes potent ability at reducing estrogen it will tend to reduce HDL levels, while increasing LDL levels, thus harming the cholesterol profile. For this reason, it is recommended to limit cycles of formestane to 8 weeks max.

Because formestane also has a strong affinity for the 5a-reductase enzyme it will reduce DHT levels in the body by effectively competing with testosterone for the 5a-reductase.

Formestane converts to the active androgen 4-hydroxytestosterone which has about half the anabolic potency, and about 25% of the androgenic potency as testosterone. This would suggest that fairly high doses of formestane (800-1000mg/day) could lead to some level of anabolic enhancement (although the amount required for this would surely lead to undesirably low estrogen levels).

Formestane is successfully used as a standalone during re-composition cycles to help reduce “bloat” and fat storage. It can also be used as an anti-estrogen to counter aromatization of aromatizing steroids.

Common Clones:

Formestane by Primordial Performance
Formex by Innovative Body Enhancement (IBE)
Formestane by Competitive Edge Labs (CEL)
Formadex by BCS LABS

Related Discussion

The Official Formestane Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

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Dienedione (Tren)

Diagram of molecule

Chemical Name(s):

19-norandrosta-4,9-diene-3b,17b-dione
estra-4,9-diene-3b,17b-dione
4,9 Estra
Chemical Formula: C18H22O2
Molecular Weight: 270
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 20%
AR Binding Affinity: 5
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Listed as a controlled substance
Average Dose:
100-200mg/day standalone
50-100mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Dienedione is a non-methylated steroid that converts to a steroid known as 17b-hydroxy-estra-4,9,(10)-dien-3-one (dienolone).

Although dienedione may have some anabolic activity on its own, it gets most of its effects from conversion to dienedrone by interaction with 17b-HSD. This steroids overall effects are somewhere between trenbolone and nandrolone.

Dienedione is known for causing night sweats via its powerful thermogenic effects similar to trenbolone. This thermogenic effect makes dienedione an excellent choice for dropping bodyfat during cutting cycles.

As a 19-nor this compound has decent progestational effects which may lead to gyno symptoms, libido loss and aggressive mood swings. Part of the reason gyno may be a problem with this compound is also because it lacks androgenic potency and down-regulates DHT levels during cycle, which is the body’s natural estrogen blocker.

Dienedione does not convert to estrogen, although it can still lead to the side-effects mentioned above. Because this compound is not 17aa liver toxicity is not really a concern. However some users have reported elevated liver enzyme values during cycle, although this could be related to other factors.

Users usually experience rapid gains in strength and aggression, followed by significant weight gain after several weeks. The results are generally fairly lean with only minor bloat due to the progestational effects.

Dienedione can be used as a standalone. In an effort to prevent libido loss and gyno, it may be stacked with testosterone or one of its non-aromatizing metabolites to help keep DHT levels elevated during cycle.

Common Clones:

Dienedrone by Advanced Muscle Science (AMS)
Liquidrone UTT by Advanced Muscle Science (AMS)
X-Tren by Competitive Edge Labs (CEL)
Tren Xtreme by American Cellular Labs
Tren 250 by Genetic Edge Technologies (GET)
Trena by Nutracoastal


Related Discussion

The Official Dienedione (Tren) Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

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