Ghrelin Hormone: An Ectomorph’s Solution to Muscular Weight Gain

The endogenous growth hormone secretagogue Ghrelin may play a paramount role in your quest for muscle growth. This gastric hormone stimulates hunger in mice and in humans by binding to the ghrelin receptors located in the hypothalamus and the hippocampus.


Reasons why people feel the urge to eat

Ghrelin is highest when blood sugar is low and being in a fasted state. Ghrelin is a potent endogenous growth hormone releaser, and is the strongest of the secretagogues. Even though it increases growth hormone release, some of its effects are quite different from growth hormone itself. Ghrelin encourages lipogenesis, whereas growth hormone supports lypolysis. Ghrelin also supports glucose oxidation, while growth hormone suppresses insulin production for inhibited glucose disposal. This equates to ghrelin being highly effective for weight gain through adipogenic pathways and growth hormone supporting weight loss through lipolytic pathways.

Ghrelin Effects:                                            Synthetic Growth Hormone Effects:

-Increases endogenous GH                                -Synthetically derived

-Encourages lipogenesis (fat gain)                     -Encourages lipolysis (fat loss)

-Increases glucose oxidation                             -May promote insulin resistance

-Great for weight gain                                       -Great for fat loss

Knowing such facts makes it very clear that ghrelin would be perfect for the ectomorphic, hard gainer body type. If you are someone who frequents the bodybuilding internet forums, then you are probably aware of the recent surge in popularity with research peptide companies. These companies sell a product called GHRP-6, which is a hexapeptide comprised of 28 amino acids that signals the pituitary to secrete growth hormone through increasing ghrelin production. Using GHRP-6 in conjunction with a regimented weight training program and a meticulously planned diet, the ectomorphic trainee could consume copious amounts of high quality nutrients to achieve muscular weight gain that once seemed impossible.

– I must  mention one must be very stringent and meticulous with whom they decide to research with, meaning make sure the company is of high quality and the peptides are USA grade ingredients. A company such as Southern Research Co. has a trusted reputation and  is held in high regard in the research peptide community. 

 

References

1.) Cordido, Fernando; Isidro, Maria L.; Nemina, Rosa; Sangiao-Alvarellos, Susana, Ghrelin and Growth Hormone Secretagogues, Physiological and Pharmacological Aspect. Volume 6, Number 1, March 2009 , pp. 34-42(9)

2.) .Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ, Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
N Engl J Med. 2002 May 23;346(21):1623-30.

3.) Britt Edén Engström, Pia Burman, Camilla Holdstock and F. Anders Karlsson,
Effects of Growth Hormone (GH) on Ghrelin, Leptin, and Adiponectin in GH-Deficient Patients. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 11 5193-5198

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Are you Ready for the Andro Series?

The release of the Andro Series Project is right around the corner and is going to be a steroidal breakthrough in the supplement industry. Each compound is a Metabolic Steroid and will elicit a host of effects such as; improved metabolic rate for losing body fat, increased anabolism for accruing lean muscle mass, heightened sexual prowess for intimacy, and improved self-confidence. What there won’t be are numerous hazardous side effects that are commonly seen with the current line of designer steroids and illegal anabolic steroids. The Andro Series has been meticulously formulated to avoid excessive stress on the liver, kidneys and heart. However, please don’t mistake a lack of side effects for a lack of results. Delivery is everything when it comes to a product being active and effective, and we have established the best in oral delivery and bio-availability.

Stack AndroMASS with AndroHARD for extreme muscular weight gain

I would like to prepare you for how to optimize and maximize your experience when incorporating the Andro Series products into your nutrition and training regimen. I would advise anyone who has experienced a training layoff due to injury, illness or laziness to first get back into the swing of things before utilizing hormonal supplementation. You will be growing regardless so it would give Andro Series a false sense of effectiveness. Once you have hit a training and nutrition plateau then it is time to implement a steroid cycle. Depending on your goals, whether it is ultimate muscle gain or extreme fat-loss you must choose the proper products to accommodate your target goal. For extreme muscular weight gain, stacking Andro Mass with Andro Hard would provide an ideal hormonal environment. The Andro Mass would be the “meat and potatoes” of the stack, yielding high conversions to Testosterone and DihydroBoldenone. Testosterone needs no description as it is the most widely used steroid available. It is known to enhance muscle mass, increase fat-loss, and raise sex drive. DihydroBoldenone is a 5-aplha-reduced form of the steroid boldenone. It elicits mild androgenic traits and is a potent anabolic. It has been reported to bind aggressively to the androgen receptor eliciting minimal androgenic side effects and substantial transcriptional gene activity that induces extreme muscle growth. The Andro Hard will convert into DHT at a high rate, so androgenic effects will be achieved. Andro Hard displays powerful characteristics such as: an increase in strength, sex drive, and mental focus for rigorous training sessions.

AndroMASS will induce –

  • High anabolic activity
  • No toxic side effects
  • Increased muscle hardness
  • Muscular weight gain
  • Superior delivery of hormones

AndroHARD will induce –

  • Profound vascularity
  • Gyno protection
  • Magnified sex drive
  • Increased aggression
  • Superior delivery of hormones

What is the optimal nutrition plan for this mass gaining cycle?

Now that you know how these 2 products can help you in your plight for extreme mass gaining, it is on you to implement proper training and nutrition to potentiate the effects of the steroid cycle. I will not expand too much on the nutritional aspect of utilizing this stack for muscular weight gain, but I will briefly touch base on a few key dieting recommendations. Make sure to structure your meals and plan ahead so you can stay consistent with no excuses. Create a nutrition plan that coincides with your body type. Meaning, if you are an ectomorph, you can get by with a higher influx of carbohydrates (400-600 grams) and dietary fat than an endomorphic body type. The mesomorph and endomorph would benefit greatly from a modest allotment of quality carbohydrates (150-300 grams) and using essential fatty acids for their fat sources. All body types would need to adjust their protein intake depending on body weight and their carbohydrate and dietary fat requirements. A good rule of thumb for mass gaining is to ingest 1.5 grams of protein per pound of body weight. You may ask, “Why only 1.5 grams?” That is because you have adequate fat and carbohydrates to spare the protein.

Which body type are you?


Next, we will go over the goal of extreme fat-loss. Andro Hard stacked with Andro Lean would be the weapons of choice to accomplish such a goal. The Andro Lean is equipped with Super-7-Dhea, which will increase fat loss 3 times more than diet and exercise alone. Super-7-Dhea will increase fat oxidation through the mitochondria from increased thyroid output from elevated T3 levels. However, thyroid stimulating hormone and T4 levels will remain unchanged, so thyroid suppression is not an issue. Super-5-Dhea is also included to keep testosterone levels elevated for muscle preservation and increased sex drive when going on a reduced calorie diet. The ectomorph body type once again can have more liberty with their carbohydrate allotment (200-300 grams) while cutting, but keep dietary fat lower so calories are in a deficit. Cardio is usually something ectomorphs don’t have to worry about, but for general health, it is recommended 3-4 times a week for at least 20 minutes. The mesomorph would diet best on medium to low carbohydrates (100-200 grams) incorporated around training, while ingesting protein with essential fatty acids at other meals of the day. Cardio performed 5 times a week, starting at 20 minutes a day is recommended. The endomorphic body type usually responds well to very low carbohydrate intake (30-75 grams) while keeping essential fatty acids in the diet. Cardio will be a key factor in getting lean with endomorph’s, so I would recommend starting off with 30 minutes a day, 6-7 times a week. When starting a cutting phase, protein intake should get ramped up since carbohydrates and fats are reduced. I recommend 2 grams of protein per pound of body weight and adjust accordingly from there. As far as weight training is concerned, I like to see people whether dieting or bulking to base their workouts around basic free weight movements. Squats, (back and front) dead lifts, (all variations) Incline barbell and dumb bell bench presses, standing barbell curls, and bent over barbell rows should all be staples if you have no injuries inhibiting you from executing such crucial exercises.

AndroLEAN will induce –

  • Increased active thyroid output (T3)
  • Increased fatty acid uncoupling
  • Mild conversions to testosterone
  • Non stimulant thermogenesis
  • Superior delivery of hormones

It should be no surprise that having your Post Cycle Therapy planned ahead of time is always recommended. You should never start a steroid cycle without having all ancillary products and post cycle products in your possession from the beginning. There are some very effective products that stand out when choosing a proper PCT protocol. If you choose a pharmaceutical, Toremifene would be a good choice. D-aspartic-acid also has proven itself effective alongside a natural SERM-like supplement, such as Trans-Resveratrol. I would recommend running your Post Cycle Therapy for at least 4 weeks to ensure adequate recovery of natural hormones.

Toremifene molecular structure shown above:

In closing, please understand that you need to plan your steroid cycles carefully and never go into it and “wing it.” Plot out your nutrition protocol, training regimen, and PCT accordingly. Keep in mind you are suppressing your endogenous production of natural hormones so make the absolute most of your next cycle.

References:

1.)Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schanzer W, Thevis M, Voller G, Zierau O, Diel P. 17beta-hydroxy-5alpha-androst-1-en-3-one(1-testosterone) is a potent androgen with anabolic properties, Toxicol Lett. 2006 Aug 20;165(2):129-55.
 

2.)Lam P. Ly, Mark Jimenez, Tian N. Zhuang, David S. Celermajer, Ann J. Conway, and David J. Handelsman,A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency. J. Clin. Endocrinol. Metab., Sep 2001; 86: 4078 – 4088.

3.) Christos S Mantzoros, Emmanuel I Georgiadis, head, Endocrine Unita, Dimitrios Trichopoulos, professor and chiefb, Contribution of dihydrotestosterone to male sexual behavior. BMJ 1995; 310 : 1289 (Published 20 May 1995)

4.)Bobyleva V, Bellei M, Lardy H. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: Possible relationship to thermogenesis. Arch Biochem Biophys 1997;341:122-128.

5.)Bosy TZ, Moore KA, Poklis A. The effect of oral dehydroepiandrosterone (DHEA) on theurine testosterone/epitestosterone (T/E) ratio in human male volunteers. J Anal Toxicol 1998;22:455-459.


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