1-Androsterone

Diagram of molecule

Chemical Name(s):

1-androsten-3b-ol-17-one
1-Dehydroepiandrosterone
Chemical Formula: C19H28O2
Molecular Weight: NA
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 8%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
200-300mg/day Transdermally
400-600mg/day standalone (oral)
200-400mg/day when stacking (oral)
Average Cycle Length: 4-6 weeks

Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

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-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

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-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

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-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

1- Androsteronetm (1-DHEA) is a non-methylated (non 17aa) pro-steroid that must convert to 1-androstenediol (1-AD), 1-androstenedione (original 1-AD) and/or 1-testosterone to be active. The double bond in the 1st position seems to slightly enhance its ability to resist excretion by the liver.

1-Androsterone occurs naturally in the body, and is a naturally occurring metabolite of DHEA. (2) The 17b-HSD enzyme converts 1-Androsterone to 1-Androstenediol, and the 3b-HSD converts it to 1-Androstenedione. Both of these 1-AD metabolites can then be converted to 1-Testosterone. Although the 1-AD metabolites are known to have some anabolic and androgenic effects on their own, 1-Testosterone is probably where most of the effects come from with this steroid.

There is no conversion to estrogen so users will not experience bloat with this compound, nor will it have a dramatic effect on blood pressure. However one unique side effect that users have reported with this compound is a feeling of lethargy. (It appears that stacking 1-Androsterone with a nuero-active hormone such as DHEA can help reverse this effect)

1-Androsterone (and primarily its metabolites) have relatively potent androgenic effects, therefore gyno is almost never an issue. However, because of the androgenic potency, this compound could pose a mild hair loss risk for those prone to MPB. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Results from this compound generally take a couple weeks to be realized. Moderate gains of lean muscle mass and strength can be expected, but users should not expect rapid increases in size or weight with this compound since extra-cellular and intra-cellular water retention are very minimal. This makes the gains from this steroid fairly easy to maintain post cycle.

1-Androsterone will stack well with almost any compound. For more dramatic gains in size and strength it is recommended to stack this compound with an aromatizing steroid or possibly one of the progestational compounds listed elsewhere.

Common Clones:

1-T by Primordial Performance
1-Androsterone by Advanced Muscle Science (AMS)

Related Discussion

The Official 1-Androsterone Thread
Posted by Eric

References

1. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties.

A Friedel, et al.
Toxicol Lett, Aug 2006; 165(2): 149-55.

2. “Metabolism of 1-Dehydroandrostanes in Man”
Galletti and Gardi, et al.
J Steroid Biochem, 3 (1972), 933-936

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1,4-AD (Boldione)

Diagram of molecule

Chemical Name(s):

1,4-androstadiene-3b,17b-dione
androst-1,4-diene-3b,17b-dione
1,4-Androstenedione
Chemical Formula: C19H24O2
Molecular Weight: 284.4
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 8%
AR Binding Affinity: NA
SHBG Binding Affinity: Low
Half Life: NA
Legal Status (US): Listed as a controlled substance
Average Dose:
800-1500mg/day standalone
400-1000mg/day when stacking
Average Cycle Length: 6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Boldione is NOT a 17-alpha alkylated steroid, therefore high doses must be taken to accommodate for its rapid excretion from the liver.

Boldione itself likely does not have any significant anabolic or androgenic value. However after interaction with the 17b-HSD enzyme, boldione is converted to the illegal anabolic steroid boldenone. Boldione can also be converted to 1-androstenedione (1-AD) and/or 1-testosterone after interaction with the 5a-reductase enzyme. These metabolites are where this pro-hormone gets most of its effects.

Since boldione is a dione, conversions to the more powerful steroid metabolites are expected to be near 15-20%, which is another reason why such high doses are needed to see results.

This pro-hormone (and its metabolites) do not convert very readily to estrogen, so an aromatase inhibitor would likely not be needed during a cycle.

Results can be expected to kick in slowly after several weeks. Moderate gains in size and strength should be expected. This compound also has a tendency to increase appetite, which makes it a good choice for bulking.

Side effects are minimal with boldione, but can become more noticeable with doses above 1000mg/day. Side-effects may include increases blood pressure and oily skin. Overall, results and side-effects would be similar to that of boldenone, including lean mass gains with low bloating. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Although this compound can be used as a standalone, it is recommended to stack this compound with an already active steroid, as the high doses of boldione will likely saturate most of the steroid conversion enzymes.

Common Clones:

BOLD by IForce
EQ-Plex by Competitive Edge Labs (CEL)
BOLD 200 by IForce
EQ-Jet by Molecular Development
P-Bold by Proven Products


Related Discussion

The Official 1,4-AD (Boldione) Thread
Posted by Eric

References

“Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle: 1. Metabolite profiles of boldenone, boldenone esters and boldione in cattle urine.”

Bruno Le Bizec, Frédérique Courant, Isabelle Gaudin, Emanuelle Bichon, Blandine Destrez,
Robert Schilt, Rosa Draisci, Fabrice Monteau and François André
Steroids; Volume 71, Issues 13-14, December 2006, Pages 1078-1087


“An
in vitro study on metabolism of 17β-boldenone and boldione using cattle liver and kidney subcellular fractions”
R. Merlanti, G. Gallina, F. Capolongo, L. Contiero, G. Biancotto, M. Dacasto and C. Montesissa

“Pathology of the testicle and sex accessory glands following the administration of boldenone and boldione as growth promoters in veal calves”
Cannizzo, F.T.(Universita degli Studi di Torino (Italy)); Zancanaro, G.; Spada, F.; Mulasso, C.; Biolatti
Nov 2007 Veterinary science and hygiene

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