Methylstenbolone

Diagram of molecule

Chemical Name(s):
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one
Chemical Formula: C21H32O2
Molecular Weight: 316.5
CAS: NA
Q Qatio: 3.9
Anabolic #: 660
Androgenic #: 170
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
5-20mg/day standalone
1-5mg/day when stacked
Average Cycle Length: 2-4 weeks

 

Stimulator
Inhibitor

 

 
-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

 

Characteristics

Although this compound cannot convert to estrogen, it will bind strongly to SHBG, thus increasing freely circulating estrogen (and testosterone). While there is a lack of anecdotal feedback from this compound to tell the real world effect this compound may have on causing gyno, experience with related compounds tell us gyno symptoms may occur.

Users should be very careful with methylstenbolone and start out with a very low dose. This compound will likely produce a rapid increase in intracellular water retention by inhibiting 11-beta hydroxylase and building up levels of mineralcorticoids that will encourage sodium and water retention.

Gains upwards of 20-25lbs in 4 weeks are probably possible with this compound. However the liver toxicity issues would likely be the first reason why someone wouldn’t be able to make incredible gains from this compound. For this reason it would be extremely important to pre-condition the liver with a liver protecting supplement prior to cycling this compound, while continuing use throughout the cycle and during PCT.

The strength increases from this compound will likely encourage weight lifting heavier than tendons and joints are prepared to lift. It is recommended to be cautious of this and to naturally build up strength levels prior to cycling this steroid.

Using a low dose of methylstenbolone with a moderate dose of a non-methylated compound would be an acceptable way to try to limit the side-effects from this compound, although caution would still need to be taken for liver health no matter what dose is used.

Because of the strength and weight gain this compound would offer it would likely be best used as part of a bulking cycle.

Availability: 

UltraDrol by Antaeus Labs

Related Discussion

The Official Methylstenbolone Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

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Desoxymethyltestosterone (Pheraplex, DMT, Madol)

Diagram of molecule

Chemical Name(s):
17a-methyl-etioallocholan-2-ene-17b-ol
17a-methyl-5a-androst-2-ene-17b-ol
Chemical Formula: C20H32O
Molecular Weight: 288
CAS: NA
Q Qatio: 6.5
Anabolic #: 1200
Androgenic #: 187
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~9 hours
Legal Status (US): Listed as a controlled substance
Average Dose:
40-60mg/day standalone
10-30mg/day when stacked
Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
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-2
-1

0
1
2
3
4
5

Characteristics

Desoxymethyltestosterone (DMT) is a 17aa steroid with equal toxicity as other 17aa oral steroids. While nearly all anabolic steroid molecules have a 3-keto group, Desoxymethyltestosterone lacks it, and has a 2-ene structure. This compound is readily active and does not require conversion.

DMT does not aromatize, nor does it appear to have any progestational activity, yet some users still experience gyno symptoms and bloat from this compound. This is likely related to the lack of androgenic potency from this compound (to antagonize the effect of estrogen). DMT may also contribute to gyno by displacing estrogen (and testosterone) from SHBG. It has also been proposed that DMT can inhibit 11b-hydroxylase and thus increase intracellular sodium and water retention by building up mineralcorticoid levels.

Depending on where you look, DMT has been reported to be 2-12 times more anabolic and 0.4-2 times as androgenic as methyltestosterone. It has been proposed that DMT is a naturally occurring substance because it has an almost identical structure to delta 2-androstenol, a naturally occurring pheromone in mammals. However, being a 17aa steroid hormone makes it synthetically altered and not naturally occurring. Either way, it is now a controlled substance in the United States.

Users should expect significant strength increases, weight gain, and bloat. Weight gains upwards of 20lbs in 4-6 weeks are not unheard of with this compound. The most obvious physical side effects will be strong muscular pumps, shortness of breath, high blood pressure, oily skin, and bloating. If users wanted to minimize toxic effect on the liver or other side effects, DMT could be used at doses as low as 10mg/day for a decent effect.

Being that this compound is methylated, it should not be stacked with other methylated compounds. Having moderately low androgenic activity, DMT may negatively affect the libido and erectile function. This side effect could be offset by stacking DMT with testosterone or one of its non-aromatizing metabolites to preserve DHT levels.

Common Clones:

P-Plex by Competitive Edge Labs (CEL)
Phera-Plex by Anabolic Xtreme
Nasty Mass by Purus Labs
Phera-VOL by Engineered Sports Technology (EST)
PheraFLEX by IForce
D-Stianozol by Nutracoastal
Pheradrol by PH Design
P-Max by Growth Labs
Phera-MAX by Generic Labs
Phera-BOL by Juggernaut Nutrition
Phera-Mass by Kilo Sports
Straight Phlexed by Black China Labs

Related Discussion

The Official Desoxymethyltestosterone (Pheraplex, DMT, Madol) Thread
Posted by Eric

References

“Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping”

P. Diel, A. Friedel, H. Geyer, M. Kamber, U. Laudenbach-Leschowsky, W. Schänzer, M.
Thevis, G. Vollmer and O. Zierau
Toxicology Letters; Volume 169, Issue 1, 28 February 2007, Pages 64-71

Promestanolone

Diagram of molecule

Chemical Name(s):
17a-methyl etioallocholan 17b-ol 3-hydroxyimine
Chemical Formula: C20H33NO2
Molecular Weight: 319.5
CAS: NA
Q Qatio: 2.4
Anabolic #: 380/24
Androgenic #: 158/20
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: High
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
75-100mg/day standalone
50-75mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][][]
-5
-4
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-2
-1

0
1
2
3
4
5

Prostate Enlargement

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-5
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-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
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-1

0
1
2
3
4
5

Lethargy

[]
-5
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-1

0
1
2
3
4
5

Characteristics

Promestanolone is a 17aa pro-steroid which converts to the illegal anabolic steroid methyl-DHT (mestanolone).

There is no human clinical data on promestanolone, but it is most likely exerting its effects by converting to methyl-DHT. The acidic environment in the stomach would be responsible for converting the 3-hydroxyimine group to a 3-one — thus rapidly changing it to methyl DHT. Therefore results and side-effects would be considered to be very similar to methyl-DHT.

Although DHT can be deactivated in skeletal muscle tissue by 3b-HSD it is likely that this enzyme pathway can be overwhelmed if this compound is taken at a high enough dose. Methyl-DHT has some activity on the progestin receptor, but not to a high degree. It has moderate anabolic but high androgenic effects. It binds strongly to SHBG, therefore free testosterone and estrogen can be expected to rise by displacement from SHBG.

Since this is a 17aa compound, liver toxicity will be an issue with high doses or long term use. For this reason users should consider priming the liver with a liver supporting supplement before and during a Promestanolone cycle. Users will also experience minimal subcutaneous water retention since there is no conversion to estrogen. However, intracellular water and sodium retention will increase by inhibition of 11-beta hydroxylase and mineralocorticoid build up.

Users may also experience an increase in aggression and mood swings which is a common side effect of many steroids with high androgenic value. This makes this compound an excellent pre-lifting or pre-competition steroid.

Promestanolone should produce solid lean gains in muscle as a standalone. However for those looking to add additional bulk to their cycle, promestanolone would stack with with virtually any other non-17aa oral.

Common Clones:

D-Plex by Competetive Edge Labs (CEL)
The ONE by Applied Nutraceuticals


Related Discussion

The Official Promestanolone Thread
Posted by Eric

References

“Effect of 1-alkyl substitution on the biological action in a series of androstanes.”

Cekan Z, Pelc B.
Steroids. 1966 Aug;8(2):209-18.

“Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.”
Saartok T, Dahlberg E, Gustafsson JA.
Endocrinology. 1984 Jun;114(6):2100-6.

7,8-Benzoflavone Carcinogenic?

7,8-benzoflavone October 14th, 2009 – A search on Google for 7,8-benzoflavone yields a link to a blogger who appears to have the opinion that 7,8-benzoflavone is a dangerous carcinogenic substance. They based this opinion on several studies which combined high levels of well known cancer causing substances, with 7,8-benzoflavone. They provided no references showing 7,8-benzoflavone is a carcinogenic substance in and of itself.

The first reference discusses the carcinogenbenzo[a]pyreneas being highly carcinogenic and that when combined with 7,8-benzoflavone, this can increase the rate of tumor formation. While this is true, this particular study foundzero tumor formation when 7,8-benzoflavone was used alone, and it in fact inhibited tumor formation caused by the more potent carcinogen7,12-dimethylbenz(a)anthracene(DMBA), thus offering a net protective effect against tumor formation. (1)

Other studies have also shown 7,8-benzoflavone has protective effects against cancer by inducing 2-hydroxylation of estrogens, thus increasing the clearance of estrogens and reducing cancer risk. (2-4)

Isolating flavonoids and carcinogens together in an in-vitro environment is a popular cancer research practice for studying the metabolism of cancer causing substances. Virtually all natural flavonoids (exp., quercetin, tangeretin, chrysin or nobiletin) have been found to negatively or positively metabolize carcinogenic chemicals in special test tube environments. However the research clearly shows a net anti-cancer effect from naturally occurring flavones. (5-7)

-Eric Potratz
Founder & President


References

1. Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding.
Nadao Kinoshita et al.
Proc Natl Acad Sci U S A. 1972 April; 69(4): 824-828

2. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone
GE Schwab, JL Raucy and EF Johnson
Volume 33, Issue 5, pp. 493-499, 05/01/1988

3. Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.
M Rahman, C Hayes Sutter, GL Emmert, and TR Sutter
Toxicol Appl Pharmacol, November 1, 2006; 216(3): 469-78.

4. Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland
Misty Prince, Cheryl T. Campbell, Taylor A. Robertson, Amy J. Wells, and Heather E. Kleiner
Carcinogenesis, Jun 2006; 27: 1204 – 1213.

5. Dietary Flavonoids and the Risk of Colorectal Cancer
Evropi Theodoratou, et al.
Cancer Epidemiol. Biomarkers Prev., Apr 2007; 16: 684 – 693

6. Flavonoids and the Risk of Oral and Pharyngeal Cancer: A
Case-Control Study from Italy
Lagiou, et al.
Cancer Epidemiol. Biomarkers Prev., Aug 2007; 16: 1621 – 1625.

7. A Review of the Epidemiological Evidence on Tea, Flavonoids, and Lung Cancer
Ilja C. W. Arts
J. Nutr., Aug 2008; 138: 1561S – 1566S

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