What is the difference between DHEA 1-DHEA 4-DHEA R-DHEA and 7-DHEA?


DHEA
(dehydroepiandrosterone)
(Super-5-DHEA†)
 
Main effects
 
+ Anti-aging (youthful energy)
+ Exercise endurance
+ Recovery
+ Fat loss
+ Muscle sparing (anti-catabolic)
+ Immune system
 
 
Primary metabolite –
 
5-androstenediol (5-AD)
 
Description –
 
DHEA is considered "generic" or regular DHEA. It can technically be called 5-DHEA, since the double bond is located in the 5th position. 
 
DHEA has been popular in the life extension crowd since the 1980’s. It's typically used for its ability to support energy and general wellbeing at a dose of 50-100mg/day. (1-3) More recently, higher doses of DHEA have been used to improve body composition due to DHEA’s mild anabolic and thermogenic effects. (1, 4) This makes DHEA an excellent choice for cutting during a calorie deficient diet, since DHEA has good muscle sparing properties. (1, 17)
 
DHEA converts to testosterone at a rate of about 1%, however it has high conversion to 5-androstenediol, where it gets its mild androgenic and anabolic effects. (5-8) DHEA’s thermogenic properties come from its conversion to 7-oxo-DHEA. (4)
 
Due to DHEA’s mild androgenic effects it rarely produces hair loss or acne. Although DHEA has moderate estrogenic effects, it rarely produces gyno or undesirable estrogenic side effects.(1-3) Some more sedentary users have reported anxiety or sleeplessness with DHEA, which is likely related to the neurosteroid activity in the brain. (3) However, this effect is also reported as “motivational energy” which is a frequently reported benefit of DHEA. 
 
Because of DHEA’s wide range of benefits and its balanced hormonal properties it can easily be used for cutting, or to keep gains lean during a lean mass building cycle.
 

4-DHEA
(4-dehydroepiandrosterone)
(Super-4-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Blood volume (hematopoietic)
+ Recovery
+ IGF-1 & GH
 
 
Primary metabolite –
 
4-androstenediol (4-AD)
 
Description –
 
4-DHEA is a naturally occurring DHEA isomer. It’s structure closely resembles regular DHEA but the double bond in the 4th position dramatically changes its effects.
 
4-DHEA readily converts to 4-androstenediol, rather than 5-androstenediol, boosting its anabolic potency more than 2x over regular DHEA. (6-8, 11) 4-DHEA is also expected to have a higher conversion rate to testosterone compared to regular DHEA. (6, 7) The 4-DHEA also lacks the calorie burning thermogenic properties, therefore offering superior calorie retention for a bulking effect. (4) This increased anabolic potency and reduced thermogenic action will lead to noticeable gains in strength, lean tissue growth, and weight gain. 
 
4-DHEA will have mild estrogen conversion that can be easily balanced with a non-aromatizing steroid like androsterone or 1-DHEA. Overall gains will be similar to the original “4-AD” banned in the 2004 Steroid Control Act.
 
As with the other DHEA isomers, 4-DHEA is naturally occurring and non-toxic. (9) Side-effects such as oily skin or reduced fertility are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. Overall 4-DHEA is a very safe and effective lean muscle building agent.
 
The only downfall to 4-DHEA is its high cost due to the high dose that is required to see significant muscle building effects.
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

1-DHEA
(1-dehydroepiandrosterone)
(Super-1-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Hardening
+ Bloat reduction
+ Recovery
 
 
Primary metabolite –
 
1-androstenediol (1-AD)
 
Description –
 
1-DHEA is a naturally occurring DHEA isomer which cannot convert to testosterone or estrogen — but instead converts to the non-estrogenic 1-testosterone. (10)
 
The total conversion to 1-testosterone is probably less than 2%. (6,7) However, 1-DHEA gets most of its effects from conversion to 1-androstenediol, which has potent muscle building and hardening effects in and of itself. (8, 11, 12) 1-androstenediol was sold as “1-AD” prior to the 2004 Steroid Control Act, and was known for producing rapid gains in lean mass with zero water retention or bloat.
 
1-DHEA does not convert to estrogen nor does it activate the estrogen receptor like DHEA is known to do. (13) It could be referred to as “dry DHEA”. Because of this, it will stack well with other estrogenic steroids such as 4-DHEA to produce† clean gains in muscle tissue.
 
As with the other DHEA isomers, 1-DHEA is naturally occurring and non-toxic. (14) Side-effects such as oily skin, reduced fertility or increased hair shedding are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. This makes 1-DHEA a very safe, legal and effective lean muscle building agent. Some users have reported lethargy with 1-DHEA. This seems to be less severe when balanced with DHEA or 4-DHEA which tend to have an anti-lethargic effect.

7-oxo-DHEA
(7-oxo-dehydroepiandrosterone)
(Super-7-DHEA†)
 
Main effects –
 
+ Fat loss
+ Weight loss
+ Muscle sparing (anti-catabolic)
+ Immune supporting
 
 
Primary metabolite –
 
Androstenetriol (AET)
 
Description –
 
7-oxo-DHEA is a naturally occurring metabolite of DHEA. It’s well known for its weight loss effect due to its strong thermogenic action. (4, 15, 16)
 
The strong thermogenic effect from 7-oxo-DHEA come from its ability to increase two thermogenic enzymes, which increases the body’s ability to burn off calories as heat. (4) Although DHEA shares a similar effect, 7-oxo-DHEA is about 2.5x more active than DHEA. (4) Human studies have shown that 7-oxo-DHEA can increase weight loss, with a majority of weight loss being actual fat tissue. (15-16) Aside from the thermogenic action, 7-oxo-DHEA also appears to be an aromatase inhibitor, which can reduce estrogen levels. 
 
Because of the modification in the 7th position, 7-oxo-DHEA cannot convert to testosterone or estrogen, nor does it have any androgenic or anabolic effects. (15) Because of this, it does not produce side-effects such as hair loss, acne or prostate inflammation. It also blocks the catabolic effect of cortisol, which helps to retain muscle during a low calorie diet.
 
Side-effects of 7-oxo-DHEA may include anxiety or sleeplessness similar to regular DHEA due to the neuro-stimulating effect. However, this is generally mild, and seems to only occur in some users. Overall 7-oxo-DHEA is very tolerable and safe at the typical 100-200mg/day dose. (15, 16)
 
While 7-oxo-DHEA can be useful for a cutting or weight loss protocol, it would not be wise to use during a bulking or mass building cycle. Its tendency to increase the metabolism and rate of calorie burning will make it difficult to build additional muscle mass. (4)
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

R-DHEA
(androsterone)
(Super-R-DHEA†)
 
Main effects –
 
+ Strength 
+ Hardening
+ Bloat reduction
+ Recovery
+ Anti-estrogen
+ Sex drive
+ Aggression 
 
 
Primary metabolite –
 
Androstanediol (5-AA)
 
Description –
 
R-DHEA is known as “Reduced DHEA” because it is a 5a-reduced metabolite of DHEA. It’s more commonly referred to as androsterone.
 
This naturally occurring hormone cannot convert to testosterone, but instead converts to the dihydrotestosterone (DHT). (10, 18) Similar to testosterone, DHT is responsible for masculine traits such as aggression, sex drive, and physical strength. (19,20) However, because DHT cannot convert to estrogen, it also helps reduce fat storage and water retention, making it an excellent steroid for increasing muscular hardness and vascularity. 
 
R-DHEA will stack well with 5-DHEA or 4-DHEA as it will help reduce water retention from under the skin, thus creating a “dry” and hard appearance. R-DHEA also has moderate anabolic properties thus allowing it to help enhance lean muscle gains. (21)
 
Strength gains will also be noticeable with R-DHEA due to its strong androgenic effect which will activate the central nervous system and increase muscular power. (20) This will increase explosive power with minimal bodyweight increase. The increased aggression is typically a welcomed benefit, which manifests as increased confidence and an “alpha male” feeling in sexual and social activities. 
 
The strong androgenic action from R-DHEA will also help support libido and erection hardness. (20) This makes R-DHEA useful to help counter the sexually suppressive effects from other steroids. The powerful androgenic effect will also block estrogenic effects, and help prevent (and reverse) gyno. (22, 23)
 
Side-effects from R-DHEA will be limited to androgenic side-effects such as oily skin, acne, and increased hair shedding if the user is prone. These side effects are mild and temporary for most users.
 
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.
References –
 
1. DHEA treatment for HIV patients: Effects on mood, androgenic and anabolic parameters. 
Rabkin, J., et al. 
Psychoneuro endocrinology. R. 25, 53-68. 2000
 
2. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. 
Khorram O, et al.
J Gerontol 1997; 52A:M1- M7.
 
3. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales AJ, et al
J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7. Erratum in: J Clin Endocrinol Metab 1995 Sep;80(9):2799.
 
4. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.
LARDY H, et al. 
Proc Natl Acad Sci USA 92: 6617-6619, 1995.
 
5. Dehydroepiandrosterone: kinetics of metabolism in normal men and women.
Bird CE et al.
J Clin Endocrinol Metab. 1978 Oct;47(4):818-22.
 
6. In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man.
Horton R, et al.
J Clin Endocrinol Metab. 1967 Jan;27(1):79-88.
 
7. In vitro metabolism of androgens in whole human blood.
Blaquier et al.
Acta Endocrinol (Copenh). 1967 Aug;55(4):697-704. No abstract available.
 
8. Androgens and anabolic agents
Julius A. Vida
Chemistry and pharmacology (1969) 
 
9. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C.
THOMAS et al.
J Biol Chem. 1964 Mar;239:766-72
 
10. Seized designer supplement named “1-Androsterone” identification as 3b-hydroxy-5a-androst-1-en-17-one and its urinary elimination.
Maria K et al.,
Steroids. 2011 Feb 16.
 
11. Circulating bioactive androgens in midlife women.
Chen et al.
J Clin Endocrinol Metab. 2006 Nov;91(11):4387-94. Epub 2006 Aug 29.
 
12. Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
Chen Fet al.
J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):247-57.
 
13. Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen et al.
Endocrinology. 2005 Nov; 146(11):4568-76. Epub 2005 Jun 30
 
14. Testosterone metabolism revisited: discovery of new metabolites.
Pozo, et al.
Anal Bioanal Chem. 2010 Oct;398(4):1759-70. 
 
15. A randomized, double blind, placebo controlled study of 3 – acetyl – 7 – oxo – dehydroepiandrosterone in healthy overweight adults. 
Kalman, D., et al. 
(2000). Curr. Ther. Res. 61, 435-442.
 
16. The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. Zenk, J., et al. 
(2002). Curr. Ther. Res. 63, 263-272.
 
17. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology 
Loria RM. Et al.
1997;22 Suppl 1:S103-8.
 
18. Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology
Fernand Labrie, et al.
J Clin Endocrinol Metab. 1997 Aug;82(8):2403-9
 
19. Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone.
Hung TT, et al. 
J Steroid Biochem. 1983 Oct;19(4):1513-20.
 
20. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study.
Kunelius P, et al.
J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.
 
21. Comparative activities of compounds of the androsterone-testosterone series.
Deanesly R, et al.
Biochem J. 1936 Feb;30(2):291-303.
 
22. Treatment of persistent pubertal gynecomastia with dihydrotestosterone heptanoate.
Eberle AJ, et al
J Pediatr. 1986 Jul;109(1):144-9.
 
23. Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature.
Benveniste O et al.
Clin Infect Dis. 2001 Sep 15;33(6):891-3. 
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Methylepitiostanol (Epistane)

Diagram of molecule

Chemical Name(s):

2a,3a-epithio-17a-methyl-etioallocholan-17b-ol
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol
Chemical Formula: C20H30OS
Molecular Weight: 320.5
CAS: NA
Q Qatio: 12
Anabolic #: 1,100
Androgenic #: 91
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~6 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
10-20mg/day when stacked
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Methylepitiostanol is a methylated version of the steroid Epitiostanol. It is readily active and does not require conversion. Under the influence of heat methylepitiostanol readily breaks down to 17a-Methyl-androstan-2-en-17b-ol (DMT), a now illegal anabolic steroid.

It does not aromatize, however it is possible that methylepitiostanol may offset estrogen and testosterone from SHBG thus increase the risk of gyno for certain individuals with high SHBG levels. Gyno symptoms from this compound may also be a result of this compounds inability to form a potent androgen such as DHT (to antagonize the effects of estrogen). However, in other cases methylepitiostanol can be used to prevent or reduce gynecomastia from an estrogenic steroid by acting as an aromatase inhibitor to keep estrogen down.

It is a DHT derivative with a fairly moderate androgenic value so the chances of hair loss may be increased in certain sensitive users. Swelling of the prostate may also become an issue. The powerful estrogen suppressing action of this steroid and its 17aa stucture will cause it to negatively influence the cholesterol profile by lowering HDL and increasing LDL. It has also been reported to cause stiff joints, possibly related to its suppressive effect on estrogen levels.

Anecdotal reports of appetite suppression and general fatigue would lead one to believe that the liver stress from this 17aa compound is rather severe. For this reason it is recommended to use a liver protecting supplement prior to and during the use of this steroid.

Methylepitiostanol has a strong anabolic action that will lead to quick gains in lean muscle mass and strength with very little bloat. The gains will appear with minimal fat gain and increased vascularity.

Because methylepitiostanol can negatively affect joint comfort it is recommended to be stacked with an aromatizing or progestational compound. However, it is not recommended to stack this steroid with another 17aa oral.

Common Clones:

Epistane by Innovative Body Enhancement (IBE)
Havoc by Primaforce
Havoc by Recomp Performance Nutrition (RPN)
Epi-MAX by Anabolic Formulations
M14-E by Purus Labs
Methyl-E by Engineered Sports Technology (EST)
E-Max by Juggernaut Nutrition
E-Stane by Competitive Edge Labs (CEL)
Hemaguno by Spectra Force Research
Hemapolin by Starmark Labs
Epi-Mass by Armour Nutrition
Epidrol by Genera Labs
Methyl Freak by Rockhard Formulations
Epistrong by Mrsupps


Related Discussion

The Official Methylepitiostanol (Epistane) Thread
Posted by Eric

References

“2{alpha},3{alpha}-Epithio-5{alpha}-androstan-17ß-yl 1-Methoxycyclopentyl Ether in the Treatment of Advanced Breast Cancer —A Preliminary Clinical Trial”

SOICHI KUMAOKA, M.D., OSAMU TAKATANI, M.D., MINORU YOSHIDA, M.D., SHIGETO MIURA, M.D., TETSUTO TAKAO, M.D., YÜJI HAMANAKA, M.D., MASARU IZUO, M.D. and TADAKAZU OKADA, M.D.
Japanese Journal of Clinical Oncology 4:65-68 (1974)

“Inhibited growth in vivo of a mouse pregnancy-dependent mammary tumor (TPDMT-4) by an antiestrogen, 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (10275-S).”
Matsuzawa A, Yamamoto T.Cancer Res. 1976 May;36(5):1598-606.

“Antitumor Effect of Two Oral Steroids, Mepitiostane and Fluoxymesterone, on a Pregnancy-dependent Mouse Mammary Tumor (TPDMT-4)1”
Akio Matsuzawa and Tadashi Yamamoto
Cancer Research 37, 4408-4415, December 1, 1977

Methyl 1,4-AD

Diagram of molecule

Chemical Name(s):

17a-methyl-1,4-androstadiene-3b,17b-diol
17a-methyl-androst-1,4-diene-3b,17b-diol
1,4-Methylandrostenedione
Chemical Formula: C20H30O2
Molecular Weight: 302
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
100-150mg/day standalone

50-100mg/day with stacking

Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Methyl-1,4AD is a 17aa pro-steroid that converts to the illegal anabolic steroid methandrostenolone (Dianabol) at a rate of about 15-20%. It takes one conversion with 3b-HSD to convert methyl-1,4AD to Dianabol which probably happens fairly rapidly in the liver.

Since the average dose of Dianabol is generally 25-50mg/day with most steroid users, it is recommended to use this compound at 2-3x the dose for noticeable effects. While Methyl-1,4AD may have some activity on its own, it would be considered pretty weak until it makes the conversion to Dianabol.

Although this compound does not appear to have any progestational effects, it can convert to estrogen (methylestradiol) at a fairly decent rate. If users are very sensitive to estrogenic side-effects then an aromatase inhibitor may be taken along with this compound. However, if one is using an anti-estrogen with this steroid it begs the question, “why chose this steroid to begin with?” Most of the weight and size gains from this compound come from its estrogen conversion, therefore using an AI would noticeably limit the gains from this compound.

This compound has moderate androgenic effects, therefore users who are sensitive to hair loss should be careful with higher doses. The combined estrogenic and androgenic effects of this compound may lead to excessive prostate swelling, so frequent visits to the bathroom may become a problem. (although all steroids have this effect to degree)

Since this compound readily converts to estrogen it will likely have a lubercative effect on joints, contrary to many modern designer steroids that do not convert to estrogen and tend to cause joint pains. This would make this compound a good choice for bulking cycles where joint comfort is important for heavy weight lifting.

Because higher doses are needed with this compound, more stress is placed on the liver. As with any 17aa oral it is recommended to pre-condition the liver with a liver supporting supplement.

Users who use this at higher doses will experience similar gains to Dianabol including rapid increases in strength and size. Side-effects may include rapid weight gain, increase in blood pressure, bloating, back pumps and acne.

This compound could be used as a standalone for a bulking cycle, however users should be aware that much of the bloat and size gains from Methyl-1,4AD will be quickly lost after a cycle.

Common Clones:

M 1,4 ADD by Competitive Edge Labs (CEL)
M14-E by Purus Labs
M1, 4AD by Anabolic Formulation


Related Discussion

The Official Methyl 1,4-AD Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Methyldrostanolone (Superdrol)

Diagram of molecule

Chemical Name(s):

2a,17a-dimethyl-5a-androst-3-one-17b-ol
2a,17a-dimethyl-etiocholan-3-one-17b-ol
Chemical Formula: C21H34O2
Molecular Weight: 318
CAS: NA
Q Qatio: 20
Anabolic #: 400
Androgenic #: 20
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: High
Half Life: ~8 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
10-30mg/day standalone
5-10mg/day when stacked
Average Cycle Length: 2-4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Methyldrostanolone is a C-17 alpha alkylated steroid, originally developed by the American pharmaceutical company Syntex. This steroid is already active and does not require conversion. Methyldrostanolone is the 17aa version of the injectable steroid drostanolone (Masteron). This extra methylation makes this steroid about 3-4x more anabolic than Masteron, and slightly more anabolic than oxandrolone (Anavar). Due to the dimethylation, the toxicity of methyldrostanolone is greater than most other oral steroids. There have been many reported cases of heptatoxicity with this compound. (1-3)

Despite the fact that methyldrostanolone is a DHT derivative and cannot convert to estrogen, some users have still reported gyno like symptoms during or after a cycle. This effect is likely related to the strong SHBG binding effect and increase in freely circulating estrogen (and testosterone) from SHBG. Gyno symptoms may also be related to the fact that methldrostanolone lacks a strong DHT metabolite to antagonize the effects of estrogen (while also having a relatively low intrinsic androgenic value).

Having a fairly low androgenic value will mean that methyldrostanolone will be light on the hairline for most men. However those susceptible to male pattern baldness may still noticed accelerated hair loss during a cycle.

Because of the di-methylation, methlydrostanolone is considerably more resistant to breakdown, thus more potent per mg than most other steroids. However this makes it more liver toxic than other single methylated 17aa orals. Negative effects on the liver generally manifest as a condition known as reversible cholestasis. This is essentially a slowing or complete blockage of bile acids from the liver. Immediate signs of compromised liver function included reduced appetite and general sickness, which will soon be accompanied by yellowing of the eyes (jaundice), excessive itchiness and very dark urine. If these effects are noticed, methyldrostanolone should be discontinued immediately.

Because the effects on the liver it is very important to use a liver protecting supplement during any methyldrostanolone cycle. If not using a supplement to protect your liver, methyldrostanolone should never be used any longer than 2 weeks, with a maximum cycle length of 4 weeks with liver protection.

Other reversible side effects from methyldrostanolone may include increased blood pressure, reduced HDL cholesterol and lower back pumps.

Results wise, users should expect extreme strength increases and weight gain in a relatively short 2-4 week period. Weight gain upwards of 20lbs in 4 weeks is not unheard of with this incredibly potent compound. Although subcutaneous water gain would be minimal, intramuscular water retention should be expected. This is due to inhibition of 11b-hydroxylase and build-up of mineralcorticoids which encourage salt and water retention within the muscles. The most obvious physical effects will be improved vascularity, aggressive muscular pumps, and oily skin.

While methyldrostanolone can stack well with most other steroids, it should never be stacked with another methylated (17aa) steroid.

Common Clones:


Oxodrol 12 by IDS
Superdrol by Anabolic Xtreme
M-Drol by Competitive Edge Labs (CEL)
SD-1 by Performance Design
Methyl VOL by Engineered Sports Technology (EST)
Revenge SDX by Bioscience Technologies
S-Drol by Nutracoastal
E-Pol by Purus Labs
MethaDROL by IForce
Straight-DROL by Black China Labs
MethylDX3 by Physical Enhancing Industries
Oxevol (same as Dianevol) by Evolution Labs
Beastdrol by Mrsupps



Related Discussion

The Official Methyldrostanolone (Superdrol) Thread
Posted by Eric

References

Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol.

Beata Jasiurkowski MD, et al.
The American Journal of Gastroenterology (2006) 101, 2659-2662;

Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol (Methasteron): A Case Report and Literature Review
John Nasr and Jawad Ahmad
Digestive Diseases and Sciences

Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases”
Neeral L. et al.
Clinical Gastroenterology and Hepatology, Volume 6, Issue 2, February 2008, Pages 255-258

Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes”
Julie Gauthier, Danielle Goudreault, Donald Poirier and Christiane Ayotte
Steroids; Volume 74, Issue 3, March 2009, Pages 306-314

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