1,4,6 Androstatriene-dione (ATD)

Diagram of molecule

Chemical Name(s):

Androsta-1,4,6-triene-3,17-dione
1,4,6-androstatriene-3,17-dione
Chemical Formula: C19H22O2
Molecular Weight: 282
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: 2 days
Legal Status (US): Not listed as a controlled substance
Average Dose: 25-100mg/day
Average Cycle Length: 4-8 weeks
Stimulator
Inhibitor

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Muscle Gain

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Strength Gain

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Fat Gain (negative indicates fat loss)

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Water Retention (extra-cellular bloat)

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Aggression

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Libido

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Acne

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Hair Loss

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Prostate Enlargement

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Liver Toxicity

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Lethargy

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Characteristics

ATD is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

ATD is used for its aromatase inhibiting and testosterone boosting effect. Its effectiveness at lowering estrogen appears to be stronger than 6-oxo. It converts to 1,4,6-testosterone, which would also be expected to cause falsely high readings for a testosterone analysis.

The 1,4,6-testosterone metabolite of ATD can also bind to the androgen receptor (AR) and induce androgenic (or possibly anti-androgenic) effects similar to what is seen from 6-oxo. This would be expected since 1,4,6-testosterone has about one third the binding affinity for the AR, therefore it may interefere with the anabolic or androgenic action of hormones which bind the androgen receptor.

ATD would also be expected to interfere with production of natural testosterone by acting upon the hypothalamus pituitary testicular axis (HPTA), therefore this compound should not be used during post cycle therapy (PCT), however it could successfully be used during a cycle to help keep estrogen in control. Anecdotal reports and animal studies have also shown ATD inhibits libido and general sexual potency.

Common Clones:

Arom-X by Advanced Muscle Science (AMS)
AIFM by Anafit
ATD MAX by Anabolic Formulations
ATD-JET by Molecular Developments
Reversitol by IForce


Related Discussion

The Official 1,4,6 Androstatriene-dione (ATD) Thread
Posted by Eric

References

Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.

Exp Brain Res. 1986;64(3):407-10.
Slama A, Gogan F, Sarrieau A, Vial M, Rostene W, Kordon C.

Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
ME Kaplan and MY McGinnis
Horm Behav, Mar 1989; 23(1): 10-26.

Anabolic Pharmacology
Seth Roberts (2009)

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Turmeric Curcuminoids Aiding in Arthritis Pain

Turmeric Root Against Arthritis Pain

October 14th, 2009 – Turmeric (Curcuma longa) is a plant and member of the ginger family, and among its most important functions is its anti-inflammatory effects in the treatment of arthritis. The main component of turmeric that contributes to these medicinal properties is a family of polyphenols known as curcuminoids. Of the curcuminoids, Curcumin (diferuloylmethane – Fig. 1) is the most notable, followed by demethoxycurcumin and bisdemethoxycurcumin. These constituents are found primarily in the rhizome (root) of the plant and are responsible for its anti-arthritic properties. (1)

Curcumin functions by inhibiting the transcription factors of a cell that turn on the genes coding for inflammatory proteins including cytokines and chemokines. (2) With the expression of these genes turned off, pain from rheumatoid arthritis can be greatly reduced or eliminated. Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation of joints and of the tissue around joints. (3)

In an experiment designed to discover the mechanism of turmeric’s medicinal effects in the treatment of RA, doctors at the University Of Arizona College Of Medicine conducted experiments with female rats after inducing arthritis. (4) The results showed that turmeric extract containing a high percentage of the curcuminoids have a dramatic effect on the prevention of joint inflammation and destruction. Specifically, inflammatory cell influx, joint levels of prostaglandin E2, and periarticular osteoclast formation were all significantly reduced when turmeric extract was injected intraperitoneally (into the abdomen). (4) Curcumin is well known as a molecule that can treat a plethora of health issues without the risk of any negative side effects. (5)

-Dylan Udy

References

1. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
Altern Med Rev. 2009 Jun;14(2):141-53

2. Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthritis.
JL Funk, et al.
J. Nat. Prod. 2006, 69, 351-355

3. Rheumatoid Arthritis (RA)
William C. et al
medicinenet.com/rheumatoid_arthritis/article.htm

4. Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthritis.
JL Funk, et al.
J. Nat. Prod. 2006, 69, 351-355

5. Role of curcumin in health and disease
Leelavinothan Pari; et al.
Archives Of Physiology And Biochemistry, 114, no. 2 (2008): 127-149

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