Whats new with AndroSeries v3?

Its been nearly a year since the initial release of the AndroSeries products, yet we are back with major changes, outdoing ourselves all over again.

We hope you enjoy all the improvements of AndroSeries v3.

Major improvements for ALL products:

  1. Once per day dosing: Semi-solid liquid delivers timed released androgens for convenient dosing.
     
  2. Reduced testicular shrinkage: 24hr timed release effect mimics the body’s natural androgen release. This reduces testicular shutdown and improves recovery time.
     
  3. No lethargy or brain-fog: We improved the ratio of GABAergic isomers to eliminate the occurrence of general "tiredness" and "lethargy" reported by certain AndroHard and AndroMass users.
     
  4. Improved retention of libido: The improved ratio of GABAergic isomers, and removal of Super-1-DHEA  supports a more normalized libido. (AndroMass & AndroHard)
     
  5. Increased correlation of "Testosterone equivalent" to real world results: Case reports of AndroSeries v3 revealed a strong correlation to our re-calculated "testosterone equivalent" values.
     
  6. Safety data backed by comprehensive blood data:  Over 15 healthy male subjects where recruited for 4-8 week cycles of the AndroSeries v3 products for comprehensive pre, during and post blood analyses. (e.g. liver, kidney, cholesterol, metabolic function, etc) Full case reports can be found on the product pages.
     
  7. Eliminated/reduced post dose nausea: Previous generation of AndroSeries v2 had a 5-10% likelihood of causing immediate nausea or vomiting for individuals sensitive to the grapefruit content. Now, AndroSeries v3 contains a timed-release dose of organic grapefruit, showing elimination of negative reactions in sensitive individuals.
     

Additional  improvements for specific products:

  1. AndroLean: New AndroLean is up to 4x stronger than the previous version. The addition of high dosed 11-oxo-testosterone (Super-11-DHEA) dramatically increases the anabolic potency, while 2x more Super-7-DHEA enhances the thermogenic power.
     
  2. AndroHard: New AndroHard has 2x more active ingredient than the previous version. The balanced mix of GABAergic isomers of epiandrosterone and androsterone for eliminates feelings of  "tiredness" and "lethargy" — while enhancing mental clarity and aggression.
     
  3. AndroMass: New AndroMass is up 2x stronger than the previous version. The balanced mix of GABAergic isomers of epiandrosterone and androsterone for eliminates feelings of "tiredness" and "lethargy" — while enhancing mental clarity and aggression.
     

New "Testosterone Equivalent" values:

For simplicity sake we have calculated the activity of all the AndroSeries products in "testosterone equivalents" — which represents the total combined androgenic, anabolic and estrogenic bio-activity for the 24hr period.

We chose "testosterone equivalents"  for AndroSeries products because it can be easily comprehended and compared to other forms of testosterone  — Even though testosterone is not the main mechanism by which the AndroSeries products work. Remember, there are dozens of androgens in the body which function very similar to testosterone, and these are the androgens that are responsible for the effects of the AndroSeries.  (e.g. androstenedione, androstenediol, ect)

The following values have been established per softgel –

  • AndroDrive – 217 ng/dL
  • AndroHard – 375 ng/dL
  • AndroLean – 334 ng/dL
  • AndroMass – 450 ng/dL
  • AndroBulk – 450 ng/dL

Keep in mind, this testosterone equivalent value does not tell you how androgenic, anabolic or estrogenic each product is in relation to each other. It is only a general average of "testosterone-like" effects. If you would like to see how the effects of each AndroSeries compares, please visit our AndroSeries comparison page here – AndroSeries Effects Chart

New AndroStat & AndroStacker:

To help you find out your current testosterone level, we built the AndroStat.

Once you get your testosterone levels, begin to build the perfect stack with the AndroStacker.

 

We've taken the "testosterone equivalent" values of our AndroSeries products and built them into the AndroStacker program. This allows you to build a stack of AndroSeries products and see the benefits, side-effects and "androgen zone" — so you can make sure you are taking the optimal dose for your custom goals with minimal side-effects.

 

Questions?

Talk to a product specialist in Live Chat

Call us – 1-503-841-6702
Email us – info@primordialperformance.com
Or get registered for our free forum

 

 

What is the difference between DHEA 1-DHEA 4-DHEA R-DHEA and 7-DHEA?


DHEA
(dehydroepiandrosterone)
(Super-5-DHEA†)
 
Main effects
 
+ Anti-aging (youthful energy)
+ Exercise endurance
+ Recovery
+ Fat loss
+ Muscle sparing (anti-catabolic)
+ Immune system
 
 
Primary metabolite –
 
5-androstenediol (5-AD)
 
Description –
 
DHEA is considered "generic" or regular DHEA. It can technically be called 5-DHEA, since the double bond is located in the 5th position. 
 
DHEA has been popular in the life extension crowd since the 1980’s. It's typically used for its ability to support energy and general wellbeing at a dose of 50-100mg/day. (1-3) More recently, higher doses of DHEA have been used to improve body composition due to DHEA’s mild anabolic and thermogenic effects. (1, 4) This makes DHEA an excellent choice for cutting during a calorie deficient diet, since DHEA has good muscle sparing properties. (1, 17)
 
DHEA converts to testosterone at a rate of about 1%, however it has high conversion to 5-androstenediol, where it gets its mild androgenic and anabolic effects. (5-8) DHEA’s thermogenic properties come from its conversion to 7-oxo-DHEA. (4)
 
Due to DHEA’s mild androgenic effects it rarely produces hair loss or acne. Although DHEA has moderate estrogenic effects, it rarely produces gyno or undesirable estrogenic side effects.(1-3) Some more sedentary users have reported anxiety or sleeplessness with DHEA, which is likely related to the neurosteroid activity in the brain. (3) However, this effect is also reported as “motivational energy” which is a frequently reported benefit of DHEA. 
 
Because of DHEA’s wide range of benefits and its balanced hormonal properties it can easily be used for cutting, or to keep gains lean during a lean mass building cycle.
 

4-DHEA
(4-dehydroepiandrosterone)
(Super-4-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Blood volume (hematopoietic)
+ Recovery
+ IGF-1 & GH
 
 
Primary metabolite –
 
4-androstenediol (4-AD)
 
Description –
 
4-DHEA is a naturally occurring DHEA isomer. It’s structure closely resembles regular DHEA but the double bond in the 4th position dramatically changes its effects.
 
4-DHEA readily converts to 4-androstenediol, rather than 5-androstenediol, boosting its anabolic potency more than 2x over regular DHEA. (6-8, 11) 4-DHEA is also expected to have a higher conversion rate to testosterone compared to regular DHEA. (6, 7) The 4-DHEA also lacks the calorie burning thermogenic properties, therefore offering superior calorie retention for a bulking effect. (4) This increased anabolic potency and reduced thermogenic action will lead to noticeable gains in strength, lean tissue growth, and weight gain. 
 
4-DHEA will have mild estrogen conversion that can be easily balanced with a non-aromatizing steroid like androsterone or 1-DHEA. Overall gains will be similar to the original “4-AD” banned in the 2004 Steroid Control Act.
 
As with the other DHEA isomers, 4-DHEA is naturally occurring and non-toxic. (9) Side-effects such as oily skin or reduced fertility are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. Overall 4-DHEA is a very safe and effective lean muscle building agent.
 
The only downfall to 4-DHEA is its high cost due to the high dose that is required to see significant muscle building effects.
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

1-DHEA
(1-dehydroepiandrosterone)
(Super-1-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Hardening
+ Bloat reduction
+ Recovery
 
 
Primary metabolite –
 
1-androstenediol (1-AD)
 
Description –
 
1-DHEA is a naturally occurring DHEA isomer which cannot convert to testosterone or estrogen — but instead converts to the non-estrogenic 1-testosterone. (10)
 
The total conversion to 1-testosterone is probably less than 2%. (6,7) However, 1-DHEA gets most of its effects from conversion to 1-androstenediol, which has potent muscle building and hardening effects in and of itself. (8, 11, 12) 1-androstenediol was sold as “1-AD” prior to the 2004 Steroid Control Act, and was known for producing rapid gains in lean mass with zero water retention or bloat.
 
1-DHEA does not convert to estrogen nor does it activate the estrogen receptor like DHEA is known to do. (13) It could be referred to as “dry DHEA”. Because of this, it will stack well with other estrogenic steroids such as 4-DHEA to produce† clean gains in muscle tissue.
 
As with the other DHEA isomers, 1-DHEA is naturally occurring and non-toxic. (14) Side-effects such as oily skin, reduced fertility or increased hair shedding are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. This makes 1-DHEA a very safe, legal and effective lean muscle building agent. Some users have reported lethargy with 1-DHEA. This seems to be less severe when balanced with DHEA or 4-DHEA which tend to have an anti-lethargic effect.

7-oxo-DHEA
(7-oxo-dehydroepiandrosterone)
(Super-7-DHEA†)
 
Main effects –
 
+ Fat loss
+ Weight loss
+ Muscle sparing (anti-catabolic)
+ Immune supporting
 
 
Primary metabolite –
 
Androstenetriol (AET)
 
Description –
 
7-oxo-DHEA is a naturally occurring metabolite of DHEA. It’s well known for its weight loss effect due to its strong thermogenic action. (4, 15, 16)
 
The strong thermogenic effect from 7-oxo-DHEA come from its ability to increase two thermogenic enzymes, which increases the body’s ability to burn off calories as heat. (4) Although DHEA shares a similar effect, 7-oxo-DHEA is about 2.5x more active than DHEA. (4) Human studies have shown that 7-oxo-DHEA can increase weight loss, with a majority of weight loss being actual fat tissue. (15-16) Aside from the thermogenic action, 7-oxo-DHEA also appears to be an aromatase inhibitor, which can reduce estrogen levels. 
 
Because of the modification in the 7th position, 7-oxo-DHEA cannot convert to testosterone or estrogen, nor does it have any androgenic or anabolic effects. (15) Because of this, it does not produce side-effects such as hair loss, acne or prostate inflammation. It also blocks the catabolic effect of cortisol, which helps to retain muscle during a low calorie diet.
 
Side-effects of 7-oxo-DHEA may include anxiety or sleeplessness similar to regular DHEA due to the neuro-stimulating effect. However, this is generally mild, and seems to only occur in some users. Overall 7-oxo-DHEA is very tolerable and safe at the typical 100-200mg/day dose. (15, 16)
 
While 7-oxo-DHEA can be useful for a cutting or weight loss protocol, it would not be wise to use during a bulking or mass building cycle. Its tendency to increase the metabolism and rate of calorie burning will make it difficult to build additional muscle mass. (4)
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

R-DHEA
(androsterone)
(Super-R-DHEA†)
 
Main effects –
 
+ Strength 
+ Hardening
+ Bloat reduction
+ Recovery
+ Anti-estrogen
+ Sex drive
+ Aggression 
 
 
Primary metabolite –
 
Androstanediol (5-AA)
 
Description –
 
R-DHEA is known as “Reduced DHEA” because it is a 5a-reduced metabolite of DHEA. It’s more commonly referred to as androsterone.
 
This naturally occurring hormone cannot convert to testosterone, but instead converts to the dihydrotestosterone (DHT). (10, 18) Similar to testosterone, DHT is responsible for masculine traits such as aggression, sex drive, and physical strength. (19,20) However, because DHT cannot convert to estrogen, it also helps reduce fat storage and water retention, making it an excellent steroid for increasing muscular hardness and vascularity. 
 
R-DHEA will stack well with 5-DHEA or 4-DHEA as it will help reduce water retention from under the skin, thus creating a “dry” and hard appearance. R-DHEA also has moderate anabolic properties thus allowing it to help enhance lean muscle gains. (21)
 
Strength gains will also be noticeable with R-DHEA due to its strong androgenic effect which will activate the central nervous system and increase muscular power. (20) This will increase explosive power with minimal bodyweight increase. The increased aggression is typically a welcomed benefit, which manifests as increased confidence and an “alpha male” feeling in sexual and social activities. 
 
The strong androgenic action from R-DHEA will also help support libido and erection hardness. (20) This makes R-DHEA useful to help counter the sexually suppressive effects from other steroids. The powerful androgenic effect will also block estrogenic effects, and help prevent (and reverse) gyno. (22, 23)
 
Side-effects from R-DHEA will be limited to androgenic side-effects such as oily skin, acne, and increased hair shedding if the user is prone. These side effects are mild and temporary for most users.
 
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.
References –
 
1. DHEA treatment for HIV patients: Effects on mood, androgenic and anabolic parameters. 
Rabkin, J., et al. 
Psychoneuro endocrinology. R. 25, 53-68. 2000
 
2. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. 
Khorram O, et al.
J Gerontol 1997; 52A:M1- M7.
 
3. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales AJ, et al
J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7. Erratum in: J Clin Endocrinol Metab 1995 Sep;80(9):2799.
 
4. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.
LARDY H, et al. 
Proc Natl Acad Sci USA 92: 6617-6619, 1995.
 
5. Dehydroepiandrosterone: kinetics of metabolism in normal men and women.
Bird CE et al.
J Clin Endocrinol Metab. 1978 Oct;47(4):818-22.
 
6. In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man.
Horton R, et al.
J Clin Endocrinol Metab. 1967 Jan;27(1):79-88.
 
7. In vitro metabolism of androgens in whole human blood.
Blaquier et al.
Acta Endocrinol (Copenh). 1967 Aug;55(4):697-704. No abstract available.
 
8. Androgens and anabolic agents
Julius A. Vida
Chemistry and pharmacology (1969) 
 
9. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C.
THOMAS et al.
J Biol Chem. 1964 Mar;239:766-72
 
10. Seized designer supplement named “1-Androsterone” identification as 3b-hydroxy-5a-androst-1-en-17-one and its urinary elimination.
Maria K et al.,
Steroids. 2011 Feb 16.
 
11. Circulating bioactive androgens in midlife women.
Chen et al.
J Clin Endocrinol Metab. 2006 Nov;91(11):4387-94. Epub 2006 Aug 29.
 
12. Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
Chen Fet al.
J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):247-57.
 
13. Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen et al.
Endocrinology. 2005 Nov; 146(11):4568-76. Epub 2005 Jun 30
 
14. Testosterone metabolism revisited: discovery of new metabolites.
Pozo, et al.
Anal Bioanal Chem. 2010 Oct;398(4):1759-70. 
 
15. A randomized, double blind, placebo controlled study of 3 – acetyl – 7 – oxo – dehydroepiandrosterone in healthy overweight adults. 
Kalman, D., et al. 
(2000). Curr. Ther. Res. 61, 435-442.
 
16. The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. Zenk, J., et al. 
(2002). Curr. Ther. Res. 63, 263-272.
 
17. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology 
Loria RM. Et al.
1997;22 Suppl 1:S103-8.
 
18. Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology
Fernand Labrie, et al.
J Clin Endocrinol Metab. 1997 Aug;82(8):2403-9
 
19. Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone.
Hung TT, et al. 
J Steroid Biochem. 1983 Oct;19(4):1513-20.
 
20. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study.
Kunelius P, et al.
J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.
 
21. Comparative activities of compounds of the androsterone-testosterone series.
Deanesly R, et al.
Biochem J. 1936 Feb;30(2):291-303.
 
22. Treatment of persistent pubertal gynecomastia with dihydrotestosterone heptanoate.
Eberle AJ, et al
J Pediatr. 1986 Jul;109(1):144-9.
 
23. Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature.
Benveniste O et al.
Clin Infect Dis. 2001 Sep 15;33(6):891-3. 

4-DHEA

Diagram of molecule

Chemical Name(s):

1-androsten-3b-ol-17-one
4-Dehydroepiandrosterone
Chemical Formula: C19H28O2
Molecular Weight: 288
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
500-1000mg/day standalone
200-500mg/day when stacked
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

4-DHEA is a naturally occurring non-methylated (non-17aa) pro-steroid.

4-DHEA, like DHEA, requires a 2 step conversion process involving 3b-HSD and 17b-HSD to convert it to Androstenedione/androstenediol, and then testosterone. What makes 4-DHEA slightly different from DHEA is a double bond in the 4th position rather than the 5th. This makes 4-DHEA less estrogenic by not acting directly upon the estrogen receptor like DHEA has been found to do.

Although 4-DHEA can aromatize to estrogen it is probably not enough to cause high estrogen related side-effects.

Overall results will be similar to or the original 4-AD banned back in 2004. Higher doses of this compound will produce fairly lean gains in muscle mass, with moderate improvements in strength. This product may produce some bloat from the estrogen conversion, which could be countered by administering an aromatase inhibitor, but this will largely defeat the purpose of using this compound to begin with.

Since this compound is naturally occurring and non-methylated overall side-effects will be fairly mild. However, high doses may also lead to oily skin, acne and increased blood pressure. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Because this compound can convert to testosterone it can also convert to DHT and other 5a-reduced metabolites. This can serve as a good stack with progestational or relatively non-androgenic compounds that may create problems with libido or gyno because of lacking androgenic potency.

Although this compound is relatively safe and moderately effective, its high cost has probably been the reason for its lack of popularity.

Common Clones:

4-AD UTT by Advanced Muscle Science (AMS)


Related Discussion

The Official 4-DHEA Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

norDHEA

Diagram of molecule

Chemical Name(s):

5-estren-3b-ol-17-one
Nordehydroepiandrosterone
Chemical Formula: C18H26O2
Molecular Weight: 274
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
300-600mg/day standalone
200-300mg/day when stacked
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

norDHEA is a non-methylated (non-17aa) pro-steroid. (naturally occurring in trace amounts in humans)

norDHEA can convert to the illegal anabolic steroid nandrolone by converting to norandrostenediol/norandrostenedione, and then to nandrolone. Nandrolone is known to have stronger anabolic effects than testosterone, yet weaker androgenic effects.

norDHEA will aromatize to estrogen less than regular DHEA, but because it is a nor compound it lacks strong androgenic metabolites. For instance, after nandrolone interacts with 5a-reductase, the metabolite dihydronandrolone (DHN) is formed, which is a weaker nor-version of DHT.

Ironically, the lack of estrogen conversion from norDHEA is probably balanced by the lack of androgenic potency and progestational effects, which makes the possibility of bloating and experiencing gyno about as likely as with regular DHEA.

One difference between norDHEA and DHEA that should be considered is the fact that norDHEA will have less androgenic effects, which may pose less risk of androgenic related hair loss and/or acne. This may be a smart choice for some men, and a decent choice for women looking for a moderately anabolic compound without much androgenic effect. (to avoid masculinizing side-effects)

Because of the low bio-availability, high doses must be used to notice gains in lean muscle mass and strength. Even with higher doses, the gains will be mild to moderate. Some bloat should be expected from the estrogenic and progestational effects of the nor-steroids. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Like the other DHEA derivatives, norDHEA would be useful in a transdermal application since the enzymes needed for the conversions to more powerful metabolites are concentrated in the skin and absorption through the skin using a good transdermal delivery cream could allow for 5-10x higher absorption than oral.

This compound would stack well with almost any other steroid, except those with progestational activity.

Common Clones:

Decavol by Advanced Muscle Science (AMS)


Related Discussion

The Official norDHEA Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Transdermal Steroids – Expanded

If there is one topic that is misunderstood in the steroid community, it’s Transdermal Steroids (TS’s). The value of TS’s are under-estimated, and the science has been over looked by the vast majority. In this article, I intend to shed some light on TS’s and introduce a few new transdermal options that can offer benefits to athletes, bodybuilders and HRT patients alike.

As a developer of several transdermal products, and a counselor to a number of TRT patients; I’ve learned that a majority of men consider Androgel™ and Testim™ the only real viable topical hormones. This makes sense, being they are the most popular FDA approved testosterone gels currently available. However, there are more options to be considered. Steroid hormones such as nandrolone and boldenone offer useful advantages when delivered topically. Legal prohormones such as DHEA and pregnenolone can also offer great benefits when used topically (Found in Dermacrine). One benefit with all TS’s is their quick clearance from the body (generally less than 72hrs for most hormones). This is advantageous for PCT, when the quick clearance of hormones is desired (often a problem with long-acting injectable steroids which may take months to clear the system.)

Before we review some of the alternatives to testosterone gel, let’s take a quick look at some basic rules so we can have a better understanding of how we can manipulate the hormonal effects for our best interest.

Application site –

The site of application is one way to maximize the effectiveness of our topical hormones, while also altering the action the hormone has on the body. For instance, the skin on the front of the neck is thin and very vascular, making it ideal for systemic transdermal delivery. The skin on the shoulders and upper back – areas where you may have had acne as a teenager — are highly concentrated with steroidogenic enzymes such as 3b HSD and 17a HSD. These are the enzymes required to make hormonal conversions, such as DHEA > androstenediol > testosterone. On the flip side, the stomach area tends to carry a higher amount of the aromatase enzyme, especially if you’re prone to holding fat in the abdominal region. This would be an area to avoid applying testosterone gel, since the increased aromatase activity could increase the conversion to estrogen.

One area which can be advantageous to use for topical application is the scrotal skin. This area is extremely thin and easily penetrated by topical ingredients for systemic delivery. In fact, its absorption rate is about 4-5x more than anywhere else on the body. (1,2) This makes it the perfect spot for the delivery of topical ingredients, giving you more bank for the buck.

One thing to be aware of with scrotal applications is the higher conversion rate to DHT when applying testosterone to this area. There is heavier conversion to DHT because the scrotal skin carries a high concentration of the 5a-reductase enzyme. When the testosterone travels through the scrotal skin it interacts with the 5a-reductase enzyme and converts to DHT. This gives you a significant spike in DHT when you apply testosterone cream to your scrotum, which may or may not be a good thing. (see below for alternatives to testosterone and how to avoid the DHT)

An enlarged or irritated prostate is generally a symptom associated with high DHT. However, the DHT may not be entirely to blame. In fact, research has shown that topical DHT treatment can actually keep the prostate healthy and even reduce its size, as long as estrogen levels are also kept in control. (3,4) Plus, DHT is an antagonist of estrogen, so it’s going to help reduce gyno (male breasts) and water retention, while it also increase libido and erectile function. It could even be argued that DHT is more critical to a man’s well-being than testosterone.

Unfortunately, DHT can increase hair loss if you’re genetically prone to it, although this could be prevented if DHT levels are kept in range, bringing us to the next topic – the progesterone/DHT relationship. That’s right, progesterone can be healthy for a male too.

The word progesterone may sound frightening to some since it’s primarily known as a female hormone. However, it also offers health benefits for the male if used in very low and controlled amounts. You see, progesterone can naturally inhibit the conversion of testosterone to DHT thus helping to keep DHT in a healthy range (similar to finasteride albeit to a lesser degree). So how does this apply to real life?

Well, pregnenolone cream is legal and readily available in most counties, and as it passes the skin, pregnenolone readily interacts with the skins enzymes (3b HSD) and makes partial conversion to progesterone. (The reason for applying pregnenolone rather than strait progesterone is the added cognitive enhancements of pregnenolone.) In most cases, a 10-20mg application of pregnenolone cream would convert to sufficient amounts of progesterone to control DHT conversion from testosterone supplementation. (given via IM or topically)

If for whatever reason you don’t want to deal with combating DHT, or are extremely sensitive to its hair loss effects, you may want to consider using nandrolone or boldenone for topical application as alternatives to testosterone. If you’re lucky enough to have access to nandrolone or boldenone base powder, they are easily compounded into a topical and are perfect for transdermal delivery. These hormones are gentler on the hairline because they don’t convert to DHT. More specifically, when they interact with the 5a-reductase enzyme, they are converted to a less powerful 5a-reduced steroid, thus being ‘gentler’ than testosterone. Note: Nandrolone (Deca) can be a double edged sword given that it lacks a powerful 5a-reduced metabolite. It’s beneficial for preventing hair loss, but notorious for erectile dysfunction causes known as “Deca Dick”.

If you’re interested in staying legal and you don’t have access to AAS’s such as testosterone, nandrolone or boldenone, then DHEA is an excellent legal alternative, especially when used as a transdermal. When taken as a transdermal, DHEA is absorbed about 10x better than when taken orally. (5) Plus there is the additional benefit of increased metabolic conversion of hormones when they are taken through the skin. (6) As mentioned earlier, the shoulder and upper back skin have the highest concentration of enzymes required to make hormonal conversions (3b HSD & 17b HSD). Since DHEA is an immediate precursor to several anabolic hormones, the topical application of DHEA can cause a sharp rise in androstenediol, androstenedione and testosterone within a few hours of application. (These are the primary hormones that make Dermacrine so effective)

Remember, no matter what hormones you choose, be aware of moderation and balance.

 

References

1. Hypogonadal impotence treated by transdermal testosterone.
McClure RD et al. Urology 1991;37:224-8.

2. Testoderm TTS, Testoderm, and Testoderm with
adhesive [package inserts]. Mountain View, Calif: Alza Pharmaceuticals, 1998.

3. Percutaneous dihydrotestosterone (DHT) treatment. In: Nieschlag E, Behre HM, eds. Testosterone: action, deficiency substitution.
Schaison G, et al Berlin: Springer Verlag; 155-164. (1990)

4. Transdermal dihydrotestosterone and treatment of “andropause”.
de Lignieres B. Ann Med 1993;25: 235-41.

5. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat C Labrie, M Flamand, A Belanger, et al. Endocrinol., Sep 1996; 150: S107 – S118.

6. The in vitro metabolism of dehydroepiandrosterone in human skin.
I Faredin, et al. Med Acad Sci Hung, Jan 1967; 23(2): 169-79.

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