Your Testosterone Levels — Killing or helping you?

If you haven't gotten your testosterone level, then visit the AndroStat now.
To see what others are saying about the AndroStat, visit this thread.

If you have your testosterone level, here is what it means –

Ready to get in your zone with the AndroSeries?

Just fill out the AndroStat, and get linked to the AndroStacker to start building your AndroSeries stack. Your testosterone level will be automatically filled in, or if you already tested you can link back to the androstat from your email.

We've taken the "testosterone equivalent" values of our AndroSeries products and built them into the AndroStacker program. This allows you to build a stack of AndroSeries products and see the benefits, side-effects and "androgen zone" — so you can make sure you are taking the optimal dose for your custom goals with minimal side-effects.

References:
1. Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity.
Mauvais-Jarvis F.
Trends Endocrinol Metab. 2011 Jan;22(1):24-33. Epub 2010 Nov 5.

2. Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)–a promising drug target for the treatment of metabolic syndrome.
Masuzaki H, et al.
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62.

3. Testosterone deficiency and the metabolic syndrome.
Lunenfeld B.
Aging Male. 2007 Jun;10(2):53-6.

4. Gender differences in the cardiovascular effect of sex hormones.
Vitale C, et al
Nat Rev Cardiol. 2009 Aug;6(8):532-42. Epub 2009 Jun 30.

5. The male climacterium: clinical signs and symptoms of a changing endocrine environment.
van den Beld AW, et al.
Prostate Suppl. 2000;10:2-8.

6. Androgens and body fat distribution in men.
Pi-Sunyer FX.
Obes Res. 1993 Jul;1(4):303-5.

7. Androgens and body fat distribution.
Blouin K, et al.
J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):272-80. Epub 2007 Sep 7.

8. Testosterone and regional fat distribution.
Mårin P.
Obes Res. 1995 Nov;3 Suppl 4:609S-612S.

9. Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones.
Crewther BT, et al.
Sports Med. 2011 Feb 1;41(2):103-23. doi: 10.2165/11539170-000000000-00000.

10. Body composition and anthropometry in bodybuilders: regional changes due to nandrolone decanoate administration.
Hartgens F, et al.
Int J Sports Med. 2001 Apr;22(3):235-41.

11. Comparison of the effects of high dose testosterone and 19-nortestosterone to a replacement dose of testosterone on strength and body composition in normal men.
Friedl KE, et al.
J Steroid Biochem Mol Biol. 1991;40(4-6):607-12.

12. Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity.
Tishova Y, et al.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):1047-51.

13. Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function: The HORMA Trial.
Sattler, F et al.
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):122-9.

14. Androstenedione does not stimulate muscle protein anabolism in young healthy men.
Rasmussen BB, et al.
J Clin Endocrinol Metab. 2000 Jan;85(1):55-9.

15. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial.
King DS, et al.
JAMA. 1999 Jun 2;281(21):2020-8.

16. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men.
Brown GA, et al.
Int J Sport Nutr Exerc Metab. 2000 Sep;10(3):340-59.

17. Testosterone dose-response relationships in healthy young men.
Bhasin S, et al.
Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.

18. Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men.
Schürmeyer T, et al.
Int J Androl. 1984 Jun;7(3):181-7.

19. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.
Hall SA, et al.
J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. Epub 2008 Jul 29.

20. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.
Wu FC, et al.
J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. Epub 2008 Feb 12.

21. Prevalence of and risk factors for androgen deficiency in middle-aged men in Hong Kong.
Wong SY, et al.
Metabolism. 2006 Nov;55(11):1488-94.

22. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men.
van den Beld AW, et al.
J Clin Endocrinol Metab. 2000 Sep;85(9):3276-82.

23. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.
Wu FC, et al.
J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. Epub 2008 Feb 12.

24. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.
Hall SA, et al.
J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. Epub 2008 Jul 29.

25. Androgen treatment of abdominally obese men.
Mårin P, et al.
Obes Res. 1993 Jul;1(4):245-51.

26. Testosterone, body composition and aging.
Vermeulen A, et al.
J Endocrinol Invest. 1999;22(5 Suppl):110-6.

27. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis.
Isidori AM, et al.
Clin Endocrinol (Oxf). 2005 Sep;63(3):280-93.

28. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: effects on body composition, lipids, and psychosexual complaints.
Permpongkosol S, et al.
J Sex Med. 2010 Nov;7(11):3765-74. doi: 10.1111/j.1743-6109.2010.01994.x. Epub 2010 Aug 30.

29. Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study.
Aversa A, et al.
J Sex Med. 2010 Oct;7(10):3495-503. doi: 10.1111/j.1743-6109.2010.01931.x.

30. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study.
Kalinchenko SY, et al.
Clin Endocrinol (Oxf). 2010 Nov;73(5):602-12. doi: 10.1111/j.1365-2265.2010.03845.x.

31. Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men.
Woodhouse LJ, et al.
J Clin Endocrinol Metab. 2004 Feb;89(2):718-26.

32. The erythrocythaemic effects of androgen.
Gardner FH, et al.
Br J Haematol. 1968 Jun;14(6):611-5.

The AndroStat and why it matters

If you haven’t completed the AndroStat questionaire, please check it out here –
http://www.primordialperformance.com/store/androstat/

To see what others are saying about the AndroStat, visit this thread.

What is the AndroStat?

The AndroStat is a questionnaire designed to estimate your average total testosterone level.

It has proven to be exceptionally accurate for predicting the average total testosterone levels in men — being anywhere from 80-100% correlated to lab values for most men.

In fact, we predict that the AndroStat can give a more accurate assessment of your average monthly total testosterone level than a single blood test from the lab.

How can the AndroStat be more accurate than a blood test?

Simply because a blood test is not a true representation of your average monthly or daily testosterone levels. Rather, a single blood test only represents your testosterone level at that very moment.

Research shows that testosterone varies by as much as 25% throughout the day, or possibly even more given physiological or environmental influences. (43,44) For instance, very few individuals enjoy blood tests, and some can become quite anxiety ridden even thinking about blood tests — which can quickly reduce testosterone by causing an immediate surge in stress hormones.

Things that can immediately influence blood testosterone levels include –

  • Stress/anxiety associated with the test itself
  • Quality of sleep from the night before
  • Drug use
  • Exercise
  • Meals

Any of these factors can negatively influence testosterone levels and give a result that is not truly representational of your average daily testosterone levels.

How does the AndroStat estimate total testosterone levels?

The AndroStat calculates total testosterone levels based on data gathered from dozens of studies, including thousands of men. It takes into account a large number of testosterone altering variables including age, body composition, BMI, smoking, exercise, stress, socioeconomic status, etc. The data from the studies was combined in to a mathematical equation that make up the power formula behind the AndroStat. (1-24)

During the development of the AndroStat, we had our AndroSeries v3 product testers (15+) and a number of volunteers complete the questionnaire, and verified the results against their actual blood values for total testosterone. We used this random sampling to verify and calibrate the AndroStat formula for a high degree of accuracy.

Editorial note: Id like to give special credit to Ken Hess, who painstakingly cross examined dozens of research papers to find the strongest correlates for predicting total testosterone levels.

What does the AndroStat have to do with AndroSeries products?

Knowing your testosterone levels helps determine the optimal dose for AndroSeries products.

For instance, men with low androgens (e.g. testosterone) will naturally get more benefit from a lower dose — partly because they are more sensitive to the effects of androgens — and they don’t need as high of a dose to surpass the androgen threshold.

On the other hand, men with higher androgen levels will require a higher dose to see the same dramatic benefits — partly because they are accustomed to the effects of high/normal androgens — and they need a higher dose to surpass the androgen threshold.

NOTE: Many of the immediate effects, like increased sex drive or aggression may not be noticeable to a man with high androgen levels — as these aspects may already be optimized, where further androgens may offer no additional benefit. However, these men can still reap physical benefits from androgen supplementation. These are considered the long-term benefits from androgens.

What is the "androgen threshold"?

The "androgen threshold" is the amount you need to boost your androgen levels in order to see significant improvements in body composition and strength. (25-27)

Research shows that androgen levels (e.g. testosterone) must increase by 1000-1300ng/dl above your current level, to increase lean body mass by 10%, drop total body fat by 10%, and increase strength by 30%. (25-27) This research is based on androgen supplementation for a 16 week period, with no dietary or training intervention. However, research suggests that combining androgens with exercise and dietary intervention can accelerate the achievement of these results. (28-30)

Consider this example subject –

Beginning stats

  • 175lbs with 500ng/dL total testosterone
  • 35lbs body fat (20%)
  • 140lbs lean body mass (80%)

Subject increases his androgen levels to 2700ng/dL (6 softgels of AndroMass for 8 weeks)

Stats after 8 weeks on AndroMass

  • 186lbs with 2700ng/dL Testosterone
  • 32lbs body fat (17%)
  • 154lbs lean body mass (83%)

Therefore, since this subject increased his androgen levels by 2200ng/dL above his natural androgen level the subject was able to reduce his body fat by about 9% and increase his lean body mass by about 10%. These results may be considered normal results from an 8 week cycle of AndroMass combined with resistance training and a lean muscle promoting diet.

I got my AndroStat results, but what do they mean?

Please refer to the Your Testosterone Levels — Killing or helping you? article for interpretation of your testosterone levels.

How much will the AndroSeries products increase my "testosterone"?

AndroSeries products are rated based on "testosterone equivalent" values. This value represents the total combined androgenic, anabolic and estrogenic bio-activity for the 24hr period.

In other words, we have gone through the painstaking effort to calculate the power of each AndroSeries pill relative to its total "testosterone-like" activity.

Here are the "testosterone equivalent" values established for the AndroSeries products –

  • AndroDrive – 217 ng/dL
  • AndroHard – 375 ng/dL
  • AndroLean – 334 ng/dL
  • AndroMass – 450 ng/dL
  • AndroBulk – 450 ng/dL

The reason for using a "testosterone equivalent" value is to give a realistic expectation of results and effects that will be noticed relative to other popular forms of testosterone, such as injectable, topical or oral testosterone. It is important to note; AndroSeries products do not work by increasing testosterone levels alone. Rather, AndroSeries exert most of their effects by converting to other androgens which have similar effects as testosterone — resulting in similar effects on the body. (31-42)

Finally, these values only represent TOTAL combined androgenic, anabolic and estrogenic effects. Remember, each AndroSeries product has a different ratio of androgenic, anabolic and estrogenic effects — as seen here in the AndroSeries Effects Chart.

How do I determine proper dosages for AndroSeries products?

Just fill out the AndroStat, and get linked to the AndroStacker to start building your AndroSeries stack. Your testosterone level is automatically filled in. If you already tested you can link back to the AndroStacker from your email.

Simply click on the items you want to use, and adjust the dosage and cycle length until your desired cycle is created. Click buy. Done!

Need more help. No problem. Just give us a call

Questions?

Talk to a product specialist in Live Chat
Call us – 1-503-841-6702
Email us – info@primordialperformance.com
Or get registered for our free forum

 

 

References –
1. Testosterone deficiency and the metabolic syndrome.
Lunenfeld B.
Aging Male. 2007 Jun;10(2):53-6.

2. The male climacterium: clinical signs and symptoms of a changing endocrine environment.
van den Beld AW, et al.
Prostate Suppl. 2000;10:2-8.

3. Androgens and body fat distribution in men.
Pi-Sunyer FX.
Obes Res. 1993 Jul;1(4):303-5.

4. Androgens and body fat distribution.
Blouin K, et al.
J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):272-80. Epub 2007 Sep 7.

5. Testosterone and regional fat distribution.
Mårin P.
Obes Res. 1995 Nov;3 Suppl 4:609S-612S.

6. Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones.
Crewther BT, et al.
Sports Med. 2011 Feb 1;41(2):103-23. doi: 10.2165/11539170-000000000-00000.

7. Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity.
Tishova Y, et al.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):1047-51.

8. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.
Hall SA, et al.
J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. Epub 2008 Jul 29.

9. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.
Wu FC, et al.
J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. Epub 2008 Feb 12.

10. Prevalence of and risk factors for androgen deficiency in middle-aged men in Hong Kong.
Wong SY, et al.
Metabolism. 2006 Nov;55(11):1488-94.

11. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men.
van den Beld AW, et al.
J Clin Endocrinol Metab. 2000 Sep;85(9):3276-82.

12. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.
Wu FC, et al.
J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. Epub 2008 Feb 12.

13. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.
Hall SA, et al.
J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. Epub 2008 Jul 29.

14. Androgen treatment of abdominally obese men.
Mårin P, et al.
Obes Res. 1993 Jul;1(4):245-51.

15. Testosterone, body composition and aging.
Vermeulen A, et al.
J Endocrinol Invest. 1999;22(5 Suppl):110-6.

16. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis.
Isidori AM, et al.
Clin Endocrinol (Oxf). 2005 Sep;63(3):280-93.

17. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: effects on body composition, lipids, and psychosexual complaints.
Permpongkosol S, et al.
J Sex Med. 2010 Nov;7(11):3765-74. doi: 10.1111/j.1743-6109.2010.01994.x. Epub 2010 Aug 30.

18. Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study.
Aversa A, et al.
J Sex Med. 2010 Oct;7(10):3495-503. doi: 10.1111/j.1743-6109.2010.01931.x.

19. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study.
Kalinchenko SY, et al.
Clin Endocrinol (Oxf). 2010 Nov;73(5):602-12. doi: 10.1111/j.1365-2265.2010.03845.x.

20. Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids.
Gårevik N, et al.
J Steroid Biochem Mol Biol. 2011 Aug 22. [Epub ahead of print]

21. Effect of long-term testosterone oenanthate administration on male reproductive function: clinical evaluation, serum FSH, LH, testosterone, and seminal fluid analyses in normal men.
Mauss J, et al.
Acta Endocrinol (Copenh). 1975 Feb;78(2):373-84.

22. Testicular responsiveness to human chorionic godadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes
Hannu et al.
J. Steroid Biochem. Vol. 25, No. 1 pp. 109-112 (1986)

23. The relationship between pubertal gynecomastia, prostate specific antigen, free androgen index, SHBG and sex steroids.
Kilic M, et al.
J Pediatr Endocrinol Metab. 2011;24(1-2):61-7.

24. Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism.
Pirola I, et al.
Fertil Steril. 2010 Nov;94(6):2331.e1-3. Epub 2010 Apr 22.

25. Testosterone dose-response relationships in healthy young men.
Bhasin S, et al.
Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.

26. Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men.
Woodhouse LJ, et al.
J Clin Endocrinol Metab. 2004 Feb;89(2):718-26.

27. Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function: The HORMA Trial.
Sattler, F et al.
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):122-9.

28. Effects of anabolic steroids on the muscle cells of strength-trained athletes.
Kadi F, et al.
Med Sci Sports Exerc 31:1528–1534. (1999)

29. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy.
Sinha-Hikim I, et al.
Am J Physiol Endocrinol Metab 283:E154–E164 (2002)

30. Comparison of the effects of high dose testosterone and 19-nortestosterone to a replacement dose of testosterone on strength and body composition in normal men.
Friedl KE, et al.
J Steroid Biochem Mol Biol. 1991;40(4-6):607-12.

31. Conversion of androsterone ester to dihydrotestosterone (DHT) — with 10 hour pharmacokinetics
Draws performed by AnyLabTestNow, 714 SW Washington St, Portland, OR 97205 ,  July 2011.
Analysis performed by S.E.D. Medical Laboratories.
(Contact Primordial Performance for full report)

32. In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man.
Horton R, et al.
J Clin Endocrinol Metab. 1967 Jan;27(1):79-88.

33. In vitro metabolism of androgens in whole human blood.
Blaquier et al.
Acta Endocrinol (Copenh). 1967 Aug;55(4):697-704. No abstract available.

34. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C.
THOMAS et al.
J Biol Chem. 1964 Mar;239:766-72. No abstract available

35. Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen et al.
Endocrinology. 2005 Nov; 146(11):4568-76. Epub 2005 Jun 30

36. Serum androgen bioactivity during 5alpha-dihydrotestosterone treatment in elderly men.
Raivio et al.
J Androl. 2002 Nov-Dec;23(6):919-21.

37. In vitro bioassays for androgens and their diagnostic applications.
Roy et al.
Hum Reprod Update. 2008 Jan-Feb;14(1):73-82. Epub 2007 Dec 4.

38. Determination of androgen bioactivity in human serum samples using a recombinant cell based in vitro bioassay.
Roy et al.
J Steroid Biochem Mol Biol. 2006 Sep; 101(1):68-77. Epub 2006 Aug 8.

39. Circulating bioactive androgens in midlife women.
Chen et al.
J Clin Endocrinol Metab. 2006 Nov;91(11):4387-94. Epub 2006 Aug 29.

40. Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
Chen Fet al.
J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):247-57.

41. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.
Jasuja R, et al.
J Clin Endocrinol Metab. 2005 Feb;90(2):855-63. Epub 2004 Nov 2.

42. In vivo MRI evaluation of anabolic steroid precursor growth effects in a guinea pig model.
Tang H, et al
Steroids. 2009 Aug;74(8):684-93. Epub 2009 Mar 20.

43. Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17beta in healthy men.
Ahokoski O, et al.
Clin Chem Lab Med. 1998 Jun;36(7):485-91.

44. Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men and women using a constant infusion procedure: effect of time of day and plasma concentration on the metabolic clearance rate of testosterone.
Southren AL, et al.
J Clin Endocrinol Metab. 1967 May;27(5):686-94.

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