What is the difference between DHEA 1-DHEA 4-DHEA R-DHEA and 7-DHEA?


DHEA
(dehydroepiandrosterone)
(Super-5-DHEA†)
 
Main effects
 
+ Anti-aging (youthful energy)
+ Exercise endurance
+ Recovery
+ Fat loss
+ Muscle sparing (anti-catabolic)
+ Immune system
 
 
Primary metabolite –
 
5-androstenediol (5-AD)
 
Description –
 
DHEA is considered "generic" or regular DHEA. It can technically be called 5-DHEA, since the double bond is located in the 5th position. 
 
DHEA has been popular in the life extension crowd since the 1980’s. It's typically used for its ability to support energy and general wellbeing at a dose of 50-100mg/day. (1-3) More recently, higher doses of DHEA have been used to improve body composition due to DHEA’s mild anabolic and thermogenic effects. (1, 4) This makes DHEA an excellent choice for cutting during a calorie deficient diet, since DHEA has good muscle sparing properties. (1, 17)
 
DHEA converts to testosterone at a rate of about 1%, however it has high conversion to 5-androstenediol, where it gets its mild androgenic and anabolic effects. (5-8) DHEA’s thermogenic properties come from its conversion to 7-oxo-DHEA. (4)
 
Due to DHEA’s mild androgenic effects it rarely produces hair loss or acne. Although DHEA has moderate estrogenic effects, it rarely produces gyno or undesirable estrogenic side effects.(1-3) Some more sedentary users have reported anxiety or sleeplessness with DHEA, which is likely related to the neurosteroid activity in the brain. (3) However, this effect is also reported as “motivational energy” which is a frequently reported benefit of DHEA. 
 
Because of DHEA’s wide range of benefits and its balanced hormonal properties it can easily be used for cutting, or to keep gains lean during a lean mass building cycle.
 

4-DHEA
(4-dehydroepiandrosterone)
(Super-4-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Blood volume (hematopoietic)
+ Recovery
+ IGF-1 & GH
 
 
Primary metabolite –
 
4-androstenediol (4-AD)
 
Description –
 
4-DHEA is a naturally occurring DHEA isomer. It’s structure closely resembles regular DHEA but the double bond in the 4th position dramatically changes its effects.
 
4-DHEA readily converts to 4-androstenediol, rather than 5-androstenediol, boosting its anabolic potency more than 2x over regular DHEA. (6-8, 11) 4-DHEA is also expected to have a higher conversion rate to testosterone compared to regular DHEA. (6, 7) The 4-DHEA also lacks the calorie burning thermogenic properties, therefore offering superior calorie retention for a bulking effect. (4) This increased anabolic potency and reduced thermogenic action will lead to noticeable gains in strength, lean tissue growth, and weight gain. 
 
4-DHEA will have mild estrogen conversion that can be easily balanced with a non-aromatizing steroid like androsterone or 1-DHEA. Overall gains will be similar to the original “4-AD” banned in the 2004 Steroid Control Act.
 
As with the other DHEA isomers, 4-DHEA is naturally occurring and non-toxic. (9) Side-effects such as oily skin or reduced fertility are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. Overall 4-DHEA is a very safe and effective lean muscle building agent.
 
The only downfall to 4-DHEA is its high cost due to the high dose that is required to see significant muscle building effects.
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

1-DHEA
(1-dehydroepiandrosterone)
(Super-1-DHEA†)
 
Main effects –
 
+ Muscle mass (nitrogen retention)
+ Strength
+ Hardening
+ Bloat reduction
+ Recovery
 
 
Primary metabolite –
 
1-androstenediol (1-AD)
 
Description –
 
1-DHEA is a naturally occurring DHEA isomer which cannot convert to testosterone or estrogen — but instead converts to the non-estrogenic 1-testosterone. (10)
 
The total conversion to 1-testosterone is probably less than 2%. (6,7) However, 1-DHEA gets most of its effects from conversion to 1-androstenediol, which has potent muscle building and hardening effects in and of itself. (8, 11, 12) 1-androstenediol was sold as “1-AD” prior to the 2004 Steroid Control Act, and was known for producing rapid gains in lean mass with zero water retention or bloat.
 
1-DHEA does not convert to estrogen nor does it activate the estrogen receptor like DHEA is known to do. (13) It could be referred to as “dry DHEA”. Because of this, it will stack well with other estrogenic steroids such as 4-DHEA to produce† clean gains in muscle tissue.
 
As with the other DHEA isomers, 1-DHEA is naturally occurring and non-toxic. (14) Side-effects such as oily skin, reduced fertility or increased hair shedding are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes PCT necessary after a cycle. This makes 1-DHEA a very safe, legal and effective lean muscle building agent. Some users have reported lethargy with 1-DHEA. This seems to be less severe when balanced with DHEA or 4-DHEA which tend to have an anti-lethargic effect.

7-oxo-DHEA
(7-oxo-dehydroepiandrosterone)
(Super-7-DHEA†)
 
Main effects –
 
+ Fat loss
+ Weight loss
+ Muscle sparing (anti-catabolic)
+ Immune supporting
 
 
Primary metabolite –
 
Androstenetriol (AET)
 
Description –
 
7-oxo-DHEA is a naturally occurring metabolite of DHEA. It’s well known for its weight loss effect due to its strong thermogenic action. (4, 15, 16)
 
The strong thermogenic effect from 7-oxo-DHEA come from its ability to increase two thermogenic enzymes, which increases the body’s ability to burn off calories as heat. (4) Although DHEA shares a similar effect, 7-oxo-DHEA is about 2.5x more active than DHEA. (4) Human studies have shown that 7-oxo-DHEA can increase weight loss, with a majority of weight loss being actual fat tissue. (15-16) Aside from the thermogenic action, 7-oxo-DHEA also appears to be an aromatase inhibitor, which can reduce estrogen levels. 
 
Because of the modification in the 7th position, 7-oxo-DHEA cannot convert to testosterone or estrogen, nor does it have any androgenic or anabolic effects. (15) Because of this, it does not produce side-effects such as hair loss, acne or prostate inflammation. It also blocks the catabolic effect of cortisol, which helps to retain muscle during a low calorie diet.
 
Side-effects of 7-oxo-DHEA may include anxiety or sleeplessness similar to regular DHEA due to the neuro-stimulating effect. However, this is generally mild, and seems to only occur in some users. Overall 7-oxo-DHEA is very tolerable and safe at the typical 100-200mg/day dose. (15, 16)
 
While 7-oxo-DHEA can be useful for a cutting or weight loss protocol, it would not be wise to use during a bulking or mass building cycle. Its tendency to increase the metabolism and rate of calorie burning will make it difficult to build additional muscle mass. (4)
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.

R-DHEA
(androsterone)
(Super-R-DHEA†)
 
Main effects –
 
+ Strength 
+ Hardening
+ Bloat reduction
+ Recovery
+ Anti-estrogen
+ Sex drive
+ Aggression 
 
 
Primary metabolite –
 
Androstanediol (5-AA)
 
Description –
 
R-DHEA is known as “Reduced DHEA” because it is a 5a-reduced metabolite of DHEA. It’s more commonly referred to as androsterone.
 
This naturally occurring hormone cannot convert to testosterone, but instead converts to the dihydrotestosterone (DHT). (10, 18) Similar to testosterone, DHT is responsible for masculine traits such as aggression, sex drive, and physical strength. (19,20) However, because DHT cannot convert to estrogen, it also helps reduce fat storage and water retention, making it an excellent steroid for increasing muscular hardness and vascularity. 
 
R-DHEA will stack well with 5-DHEA or 4-DHEA as it will help reduce water retention from under the skin, thus creating a “dry” and hard appearance. R-DHEA also has moderate anabolic properties thus allowing it to help enhance lean muscle gains. (21)
 
Strength gains will also be noticeable with R-DHEA due to its strong androgenic effect which will activate the central nervous system and increase muscular power. (20) This will increase explosive power with minimal bodyweight increase. The increased aggression is typically a welcomed benefit, which manifests as increased confidence and an “alpha male” feeling in sexual and social activities. 
 
The strong androgenic action from R-DHEA will also help support libido and erection hardness. (20) This makes R-DHEA useful to help counter the sexually suppressive effects from other steroids. The powerful androgenic effect will also block estrogenic effects, and help prevent (and reverse) gyno. (22, 23)
 
Side-effects from R-DHEA will be limited to androgenic side-effects such as oily skin, acne, and increased hair shedding if the user is prone. These side effects are mild and temporary for most users.
 
 
†:The “Super” (ex., "Super-5-DHEA") signifies a fatty ester attachment to the steroid molecule to assist in bioavailability.
References –
 
1. DHEA treatment for HIV patients: Effects on mood, androgenic and anabolic parameters. 
Rabkin, J., et al. 
Psychoneuro endocrinology. R. 25, 53-68. 2000
 
2. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. 
Khorram O, et al.
J Gerontol 1997; 52A:M1- M7.
 
3. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales AJ, et al
J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7. Erratum in: J Clin Endocrinol Metab 1995 Sep;80(9):2799.
 
4. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.
LARDY H, et al. 
Proc Natl Acad Sci USA 92: 6617-6619, 1995.
 
5. Dehydroepiandrosterone: kinetics of metabolism in normal men and women.
Bird CE et al.
J Clin Endocrinol Metab. 1978 Oct;47(4):818-22.
 
6. In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man.
Horton R, et al.
J Clin Endocrinol Metab. 1967 Jan;27(1):79-88.
 
7. In vitro metabolism of androgens in whole human blood.
Blaquier et al.
Acta Endocrinol (Copenh). 1967 Aug;55(4):697-704. No abstract available.
 
8. Androgens and anabolic agents
Julius A. Vida
Chemistry and pharmacology (1969) 
 
9. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C.
THOMAS et al.
J Biol Chem. 1964 Mar;239:766-72
 
10. Seized designer supplement named “1-Androsterone” identification as 3b-hydroxy-5a-androst-1-en-17-one and its urinary elimination.
Maria K et al.,
Steroids. 2011 Feb 16.
 
11. Circulating bioactive androgens in midlife women.
Chen et al.
J Clin Endocrinol Metab. 2006 Nov;91(11):4387-94. Epub 2006 Aug 29.
 
12. Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
Chen Fet al.
J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):247-57.
 
13. Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen et al.
Endocrinology. 2005 Nov; 146(11):4568-76. Epub 2005 Jun 30
 
14. Testosterone metabolism revisited: discovery of new metabolites.
Pozo, et al.
Anal Bioanal Chem. 2010 Oct;398(4):1759-70. 
 
15. A randomized, double blind, placebo controlled study of 3 – acetyl – 7 – oxo – dehydroepiandrosterone in healthy overweight adults. 
Kalman, D., et al. 
(2000). Curr. Ther. Res. 61, 435-442.
 
16. The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. Zenk, J., et al. 
(2002). Curr. Ther. Res. 63, 263-272.
 
17. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology 
Loria RM. Et al.
1997;22 Suppl 1:S103-8.
 
18. Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology
Fernand Labrie, et al.
J Clin Endocrinol Metab. 1997 Aug;82(8):2403-9
 
19. Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone.
Hung TT, et al. 
J Steroid Biochem. 1983 Oct;19(4):1513-20.
 
20. The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study.
Kunelius P, et al.
J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.
 
21. Comparative activities of compounds of the androsterone-testosterone series.
Deanesly R, et al.
Biochem J. 1936 Feb;30(2):291-303.
 
22. Treatment of persistent pubertal gynecomastia with dihydrotestosterone heptanoate.
Eberle AJ, et al
J Pediatr. 1986 Jul;109(1):144-9.
 
23. Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature.
Benveniste O et al.
Clin Infect Dis. 2001 Sep 15;33(6):891-3. 
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Methylstenbolone

Diagram of molecule

Chemical Name(s):
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one
Chemical Formula: C21H32O2
Molecular Weight: 316.5
CAS: NA
Q Qatio: 3.9
Anabolic #: 660
Androgenic #: 170
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
5-20mg/day standalone
1-5mg/day when stacked
Average Cycle Length: 2-4 weeks

 

Stimulator
Inhibitor

 

 
-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

 

Characteristics

Although this compound cannot convert to estrogen, it will bind strongly to SHBG, thus increasing freely circulating estrogen (and testosterone). While there is a lack of anecdotal feedback from this compound to tell the real world effect this compound may have on causing gyno, experience with related compounds tell us gyno symptoms may occur.

Users should be very careful with methylstenbolone and start out with a very low dose. This compound will likely produce a rapid increase in intracellular water retention by inhibiting 11-beta hydroxylase and building up levels of mineralcorticoids that will encourage sodium and water retention.

Gains upwards of 20-25lbs in 4 weeks are probably possible with this compound. However the liver toxicity issues would likely be the first reason why someone wouldn’t be able to make incredible gains from this compound. For this reason it would be extremely important to pre-condition the liver with a liver protecting supplement prior to cycling this compound, while continuing use throughout the cycle and during PCT.

The strength increases from this compound will likely encourage weight lifting heavier than tendons and joints are prepared to lift. It is recommended to be cautious of this and to naturally build up strength levels prior to cycling this steroid.

Using a low dose of methylstenbolone with a moderate dose of a non-methylated compound would be an acceptable way to try to limit the side-effects from this compound, although caution would still need to be taken for liver health no matter what dose is used.

Because of the strength and weight gain this compound would offer it would likely be best used as part of a bulking cycle.

Availability: 

UltraDrol by Antaeus Labs

Related Discussion

The Official Methylstenbolone Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Cynostane

Diagram of molecule

Chemical Name(s):

2-cyano-17a-methyl-17b-hydroxy-androstan-3-one
2-cyano-17a-methyl-17b-hydroxy-androst-3-one (incorrect name)
Chemical Formula: C21H31NO2
Molecular Weight: 329
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
20-30mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

2-cyano-dromostolone is a 17aa molecule relatively new to the scene with very few reviews as of yet.

It has a cyano group attached to the 2 position. The chemical structure is the same as methyldrostanolone (Superdrol), except it has a CN group on the 2 position instead of a methyl group. It is a C-17aa steroid and it will be liver toxic. Although, due to the lack of the 4-ene on ring A and lack of 2-methylation, liver toxicity may be reduced relative to a di-methylated steroid such as Superdrol.

So far, feedback is very limited for this compound. However results would be expected to be fairly lean as this compound cannot convert to estrogen. Based on the chemical structure the anabolic potency would appear to be fairly potent with moderate androgenic potency.

At the time of this writing there was only one manufacturer to bring this product to the market and there seems to have been a nomenclature mistake on the labeling for this steroid. The chemical name contains the term “androst”, assuming that there is some sort of ene group on ring A. But there does not seem to be such mention of an ene group on ring A. Therefore, the term androst should be androstan. But if this is the case, the 2-cyano group needs to be stated as alpha or beta. This makes a big difference, since usually C2-alpha groups are significantly more effective than beta.

There are studies about other 2-cyano steroids such as 2-cyano-DHT and 2-cyano-progesterone. In separate studies, one done on dogs, it was seen that both of these 2-cyano steroids caused inhibition of 3b-HSD enzyme. This inhibition would cause severe adrenal suppression. This is a very unsafe inhibition. Whether it occurs in this cyano steroid is unknown, but users need to be aware of this possibility.

Common Clones:

Cynostane by Anabolic Innovation


Related Discussion

The Official Cynostane Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Androstenetrione (6-OXO)

Diagram of molecule

Chemical Name(s):

4-androsten-3,6,17-trione
3,6,17-androstenetrione
androst-4-ene-3,6,17-trione
6-ketoandrostenedione
Chemical Formula: C19H24O3
Molecular Weight: 300
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: 3-6 hours
Legal Status (US): Not listed as a controlled substance
Average Dose: 300-600mg/day
Average Cycle Length: 4-8 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

6-OXO is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

It is used for its anti-estrogen and testosterone boosting effects.

There is debate about whether or not 6-oxo actually lowers estrogen or increases testosterone. Several human studies have shown an increase in estrone levels following 6-oxo supplementation. However, one of the primary metabolites of 6-oxo is 6-oxoestrone which may have given a false positive for elevated estrone levels. The human study also concluded that 6-oxo raised testosterone levels, however it is possible that 6-oxotestosterone (which is another metabolite of 6-oxo) gave a false positive for the testosterone level as well.

Another interesting element to these articles is that despite the supposed increase in testosterone (enough to cause significant improvements in body composition if given via injection) no improvements where found for fat free mass (FFM) or strength. Therefore, 6-oxo is either a weak AI that doesn’t really inhibit estrogen at the recommended dose and simply converts to metabolites which give false readings, or it actually does increase testosterone, while the 6-oxo metabolites antagonize the androgen receptor enough to block any anabolic effect from testosterone.

Either way, no ergonomic or real world benefit could be found after 6-oxo supplementation.

Its also worth mentioning that 6-oxo should never be used post cycle, as its steroidial effects would likely interfere with recovery of natural testosterone production.


Related Discussion

The Official Androstenetrione (6-OXO) Thread
Posted by Eric

References

Immunological interference of the synthetic aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) and its metabolite(s) in the radioimmunoassay for testosterone.

MD Donaldson and MG Forest
Steroids, Dec 1980; 36(6): 717-21

Testosterone dose-response relationships in healthy young men
Shalender Bhasin, et al.
Am J Physiol Endocrinol Metab, Dec 2001; 281: E1172 – E1181.

Desoxymethyltestosterone (Pheraplex, DMT, Madol)

Diagram of molecule

Chemical Name(s):
17a-methyl-etioallocholan-2-ene-17b-ol
17a-methyl-5a-androst-2-ene-17b-ol
Chemical Formula: C20H32O
Molecular Weight: 288
CAS: NA
Q Qatio: 6.5
Anabolic #: 1200
Androgenic #: 187
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~9 hours
Legal Status (US): Listed as a controlled substance
Average Dose:
40-60mg/day standalone
10-30mg/day when stacked
Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
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Liver Toxicity

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-1

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Lethargy

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-1

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Characteristics

Desoxymethyltestosterone (DMT) is a 17aa steroid with equal toxicity as other 17aa oral steroids. While nearly all anabolic steroid molecules have a 3-keto group, Desoxymethyltestosterone lacks it, and has a 2-ene structure. This compound is readily active and does not require conversion.

DMT does not aromatize, nor does it appear to have any progestational activity, yet some users still experience gyno symptoms and bloat from this compound. This is likely related to the lack of androgenic potency from this compound (to antagonize the effect of estrogen). DMT may also contribute to gyno by displacing estrogen (and testosterone) from SHBG. It has also been proposed that DMT can inhibit 11b-hydroxylase and thus increase intracellular sodium and water retention by building up mineralcorticoid levels.

Depending on where you look, DMT has been reported to be 2-12 times more anabolic and 0.4-2 times as androgenic as methyltestosterone. It has been proposed that DMT is a naturally occurring substance because it has an almost identical structure to delta 2-androstenol, a naturally occurring pheromone in mammals. However, being a 17aa steroid hormone makes it synthetically altered and not naturally occurring. Either way, it is now a controlled substance in the United States.

Users should expect significant strength increases, weight gain, and bloat. Weight gains upwards of 20lbs in 4-6 weeks are not unheard of with this compound. The most obvious physical side effects will be strong muscular pumps, shortness of breath, high blood pressure, oily skin, and bloating. If users wanted to minimize toxic effect on the liver or other side effects, DMT could be used at doses as low as 10mg/day for a decent effect.

Being that this compound is methylated, it should not be stacked with other methylated compounds. Having moderately low androgenic activity, DMT may negatively affect the libido and erectile function. This side effect could be offset by stacking DMT with testosterone or one of its non-aromatizing metabolites to preserve DHT levels.

Common Clones:

P-Plex by Competitive Edge Labs (CEL)
Phera-Plex by Anabolic Xtreme
Nasty Mass by Purus Labs
Phera-VOL by Engineered Sports Technology (EST)
PheraFLEX by IForce
D-Stianozol by Nutracoastal
Pheradrol by PH Design
P-Max by Growth Labs
Phera-MAX by Generic Labs
Phera-BOL by Juggernaut Nutrition
Phera-Mass by Kilo Sports
Straight Phlexed by Black China Labs

Related Discussion

The Official Desoxymethyltestosterone (Pheraplex, DMT, Madol) Thread
Posted by Eric

References

“Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping”

P. Diel, A. Friedel, H. Geyer, M. Kamber, U. Laudenbach-Leschowsky, W. Schänzer, M.
Thevis, G. Vollmer and O. Zierau
Toxicology Letters; Volume 169, Issue 1, 28 February 2007, Pages 64-71

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