Methoxygonadiene

Diagram of molecule

Chemical Name(s):

13-ethyl-3-methoxy-gona-2,5(10)-diene-17-one
13b-ethyl-3-methoxy-2,5 (10)-gona-diene-17-one
Chemical Formula: C20H28O2
Molecular Weight: 300
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 20%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
50-75mg/day standalone
25-50mg/day when stacked
Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Methoxygonadiene is not a 17aa steroid so liver toxicity is not as harsh as with 17aa steorids, however the ethyl group on C-18 may make it slightly more toxic than a non-ethylated steroid (while increasing its oral bio-availability). The progestational activity of methoxygonadiene (once it is converted to its active metabolites) is considered to be slightly stronger than nandrolone.

In the stomach acid, the C-3 methoxy group is rapidly cleaved off and the double bond on the A ring at C-2 is lost. At this point, a 3-oxo is formed and a metabolite known as 13b-ethyl-nor-androstenedione is created, which is chemically similar to norbolethone, and probably where this compound gets most of its effects.

13b-ethyl-nor-androstenedione is about equal to testosterone in anabolic potency, yet less androgenic. This would make this compound fairly light on the hairline with minimal chance of acne or other androgenic side-effects.

With low androgenic activity, this compound may negatively affect the libido and erectile function. The lack of androgenic potency and progestational effects make this compound likely to cause gyno symptoms. Users could stack this compound with testosterone or one of its non-aromatizing metabolites to preserve DHT levels and possibly prevent these side-effects.

Users experience rapid weight gain from this compound partly due to subcutaneous water retention from the progestational activity. Therefore the overall gains from this compound may lead to a bloated appearance. Because of the progestational effects, users should avoid stacking this compound with other gyno aggravating compounds. Methoxygonadiene can aromatize to estrogen in small amounts, however not to any significant degree, therefore an aromatase inhibitor would provide little protection against this compounds side-effects.

Common Clones:

Revolt by KiloSports
M-LMG by Competitive Edge Labs (CEL)
X-MASS by Generic Labs
Deiselbolan by Mrsupps


Related Discussion

The Official Methoxygonadiene Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Advertisements

Halodrol

Diagram of molecule

Chemical Name(s):
4-chloro-17a-methyl-androst-1,4-diene-3b,17b-diol
Chemical Formula: C20H29C1O2
Molecular Weight: 337
CAS: NA
Q Qatio: 2.6
Anabolic #: 74
Androgenic #: 28
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~16 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
100-150mg/day standalone
50-100mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Halodrol is a 17aa steroid that converts to the steroid oral Turinabol after interaction with 3b-HSD at an estimated rate of about 5%.

Because of this low conversion, doses must be higher than other 17aa pro-steroids. However, it is suspected that Halodrol has decent potency without conversion as good results are seen despite the relatively low conversion to Turinabol. Based on Vida’s data Halodrol appears to be about as potent as testosterone, and significantly less androgenic.

Because of the 4-chloro group, halodrol has no progestational effects, it cannot interact with the aromatase enzyme, and it produces inactive 4-chloro-DHT metabolites. This makes androgenic side-effects such as hair loss, high blood pressure, acne and prostate enlargement less likely. Anecdotal reports would also have us believe that side-effects with this compound are fairly mild.

Although caution would still need to be had, the low androgenic value of this compound would also make it one of the more appropriate anabolic steroids for women wishing increase lean mass yet avoid a deeper voice, increased hair growth, acne and clitoral growth. (Oral Turinabol was actually the preferred steroid for Olympic female athletes in East Germany)

The lack of androgenic potency might be expected to create problems with gyno, however the low SHBG binding affinity has minimal interference with SHBG levels and/or freely circuiting estrogen and testosterone. It does not appear that halodrol has a significant gyno risk.

Because halodrol must be used at such a high dose to see noticeable effects, liver toxicity may become an issue. Therefore it is recommended to use a liver protecting supplement before and during halodrol cycles.

Gains from Halodrol generally take a few weeks to notice, but users can expect solid increases in strength, lean muscle mass, improved vascularity and minimal water retention. This allows some of the gains to be kept after the cycle if good diet and training are continued. Quick dramatic gains in size and strength are not generally noticed with Halodrol.

It is used successfully as a standalone, but would be expected to stack well with most other steroids, except 17aa oral due to liver toxicity concerns.

Common Clones:

Halo-MASS by Anabolic Formulations
HD-1 by Performance Design
H-Drol by Competitive Edge Labs (CEL)
Halovar by Purus Labs
Hemadrol by Engineered Sports Technology (EST)
Halodrol-50 by Gaspari Nutrition
Oral Turinadrol by Juggernaut Nutrition
Super Halo by Black China Labs
H-Drol by Nutracoastal
Helladrol by Mrsupps


Related Discussion

The Official Halodrol Thread
Posted by Eric

References

“Hepatotoxicity Associated With Dietary Supplements Containing Anabolic Steroids”

Michel I. Kafrouni, Robert A. Anders and Sumita Verma
Clinical Gastroenterology and Hepatology; Volume 5, Issue 7, July 2007, Pages 809-812

%d bloggers like this: