Methylstenbolone

Diagram of molecule

Chemical Name(s):
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one
Chemical Formula: C21H32O2
Molecular Weight: 316.5
CAS: NA
Q Qatio: 3.9
Anabolic #: 660
Androgenic #: 170
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
5-20mg/day standalone
1-5mg/day when stacked
Average Cycle Length: 2-4 weeks

 

Stimulator
Inhibitor

 

 
-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

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-5
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0
1
2
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4
5

Strength Gain

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-5
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-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

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-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

 

Characteristics

Although this compound cannot convert to estrogen, it will bind strongly to SHBG, thus increasing freely circulating estrogen (and testosterone). While there is a lack of anecdotal feedback from this compound to tell the real world effect this compound may have on causing gyno, experience with related compounds tell us gyno symptoms may occur.

Users should be very careful with methylstenbolone and start out with a very low dose. This compound will likely produce a rapid increase in intracellular water retention by inhibiting 11-beta hydroxylase and building up levels of mineralcorticoids that will encourage sodium and water retention.

Gains upwards of 20-25lbs in 4 weeks are probably possible with this compound. However the liver toxicity issues would likely be the first reason why someone wouldn’t be able to make incredible gains from this compound. For this reason it would be extremely important to pre-condition the liver with a liver protecting supplement prior to cycling this compound, while continuing use throughout the cycle and during PCT.

The strength increases from this compound will likely encourage weight lifting heavier than tendons and joints are prepared to lift. It is recommended to be cautious of this and to naturally build up strength levels prior to cycling this steroid.

Using a low dose of methylstenbolone with a moderate dose of a non-methylated compound would be an acceptable way to try to limit the side-effects from this compound, although caution would still need to be taken for liver health no matter what dose is used.

Because of the strength and weight gain this compound would offer it would likely be best used as part of a bulking cycle.

Availability: 

UltraDrol by Antaeus Labs

Related Discussion

The Official Methylstenbolone Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

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Methyl 1,4-AD

Diagram of molecule

Chemical Name(s):

17a-methyl-1,4-androstadiene-3b,17b-diol
17a-methyl-androst-1,4-diene-3b,17b-diol
1,4-Methylandrostenedione
Chemical Formula: C20H30O2
Molecular Weight: 302
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
100-150mg/day standalone

50-100mg/day with stacking

Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

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-5
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-3
-2
-1

0
1
2
3
4
5

Strength Gain

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-5
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-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[][]
-5
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-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
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-1

0
1
2
3
4
5

Lethargy

[][]
-5
-4
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-2
-1

0
1
2
3
4
5

Characteristics

Methyl-1,4AD is a 17aa pro-steroid that converts to the illegal anabolic steroid methandrostenolone (Dianabol) at a rate of about 15-20%. It takes one conversion with 3b-HSD to convert methyl-1,4AD to Dianabol which probably happens fairly rapidly in the liver.

Since the average dose of Dianabol is generally 25-50mg/day with most steroid users, it is recommended to use this compound at 2-3x the dose for noticeable effects. While Methyl-1,4AD may have some activity on its own, it would be considered pretty weak until it makes the conversion to Dianabol.

Although this compound does not appear to have any progestational effects, it can convert to estrogen (methylestradiol) at a fairly decent rate. If users are very sensitive to estrogenic side-effects then an aromatase inhibitor may be taken along with this compound. However, if one is using an anti-estrogen with this steroid it begs the question, “why chose this steroid to begin with?” Most of the weight and size gains from this compound come from its estrogen conversion, therefore using an AI would noticeably limit the gains from this compound.

This compound has moderate androgenic effects, therefore users who are sensitive to hair loss should be careful with higher doses. The combined estrogenic and androgenic effects of this compound may lead to excessive prostate swelling, so frequent visits to the bathroom may become a problem. (although all steroids have this effect to degree)

Since this compound readily converts to estrogen it will likely have a lubercative effect on joints, contrary to many modern designer steroids that do not convert to estrogen and tend to cause joint pains. This would make this compound a good choice for bulking cycles where joint comfort is important for heavy weight lifting.

Because higher doses are needed with this compound, more stress is placed on the liver. As with any 17aa oral it is recommended to pre-condition the liver with a liver supporting supplement.

Users who use this at higher doses will experience similar gains to Dianabol including rapid increases in strength and size. Side-effects may include rapid weight gain, increase in blood pressure, bloating, back pumps and acne.

This compound could be used as a standalone for a bulking cycle, however users should be aware that much of the bloat and size gains from Methyl-1,4AD will be quickly lost after a cycle.

Common Clones:

M 1,4 ADD by Competitive Edge Labs (CEL)
M14-E by Purus Labs
M1, 4AD by Anabolic Formulation


Related Discussion

The Official Methyl 1,4-AD Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Desoxymethyltestosterone (Pheraplex, DMT, Madol)

Diagram of molecule

Chemical Name(s):
17a-methyl-etioallocholan-2-ene-17b-ol
17a-methyl-5a-androst-2-ene-17b-ol
Chemical Formula: C20H32O
Molecular Weight: 288
CAS: NA
Q Qatio: 6.5
Anabolic #: 1200
Androgenic #: 187
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~9 hours
Legal Status (US): Listed as a controlled substance
Average Dose:
40-60mg/day standalone
10-30mg/day when stacked
Average Cycle Length: 4 weeks
Stimulator
Inhibitor

-5
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0
1
2
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4
5

Muscle Gain

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-5
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0
1
2
3
4
5

Strength Gain

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-5
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0
1
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4
5

Fat Gain (negative indicates fat loss)

[]
-5
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-1

0
1
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4
5

Water Retention (extra-cellular bloat)

[][]
-5
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-1

0
1
2
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4
5

Aggression

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-5
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-1

0
1
2
3
4
5

Libido

[]
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-1

0
1
2
3
4
5

Acne

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-1

0
1
2
3
4
5

Hair Loss

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0
1
2
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5

Prostate Enlargement

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0
1
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3
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5

Liver Toxicity

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0
1
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5

Lethargy

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0
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2
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Characteristics

Desoxymethyltestosterone (DMT) is a 17aa steroid with equal toxicity as other 17aa oral steroids. While nearly all anabolic steroid molecules have a 3-keto group, Desoxymethyltestosterone lacks it, and has a 2-ene structure. This compound is readily active and does not require conversion.

DMT does not aromatize, nor does it appear to have any progestational activity, yet some users still experience gyno symptoms and bloat from this compound. This is likely related to the lack of androgenic potency from this compound (to antagonize the effect of estrogen). DMT may also contribute to gyno by displacing estrogen (and testosterone) from SHBG. It has also been proposed that DMT can inhibit 11b-hydroxylase and thus increase intracellular sodium and water retention by building up mineralcorticoid levels.

Depending on where you look, DMT has been reported to be 2-12 times more anabolic and 0.4-2 times as androgenic as methyltestosterone. It has been proposed that DMT is a naturally occurring substance because it has an almost identical structure to delta 2-androstenol, a naturally occurring pheromone in mammals. However, being a 17aa steroid hormone makes it synthetically altered and not naturally occurring. Either way, it is now a controlled substance in the United States.

Users should expect significant strength increases, weight gain, and bloat. Weight gains upwards of 20lbs in 4-6 weeks are not unheard of with this compound. The most obvious physical side effects will be strong muscular pumps, shortness of breath, high blood pressure, oily skin, and bloating. If users wanted to minimize toxic effect on the liver or other side effects, DMT could be used at doses as low as 10mg/day for a decent effect.

Being that this compound is methylated, it should not be stacked with other methylated compounds. Having moderately low androgenic activity, DMT may negatively affect the libido and erectile function. This side effect could be offset by stacking DMT with testosterone or one of its non-aromatizing metabolites to preserve DHT levels.

Common Clones:

P-Plex by Competitive Edge Labs (CEL)
Phera-Plex by Anabolic Xtreme
Nasty Mass by Purus Labs
Phera-VOL by Engineered Sports Technology (EST)
PheraFLEX by IForce
D-Stianozol by Nutracoastal
Pheradrol by PH Design
P-Max by Growth Labs
Phera-MAX by Generic Labs
Phera-BOL by Juggernaut Nutrition
Phera-Mass by Kilo Sports
Straight Phlexed by Black China Labs

Related Discussion

The Official Desoxymethyltestosterone (Pheraplex, DMT, Madol) Thread
Posted by Eric

References

“Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping”

P. Diel, A. Friedel, H. Geyer, M. Kamber, U. Laudenbach-Leschowsky, W. Schänzer, M.
Thevis, G. Vollmer and O. Zierau
Toxicology Letters; Volume 169, Issue 1, 28 February 2007, Pages 64-71

Promestanolone

Diagram of molecule

Chemical Name(s):
17a-methyl etioallocholan 17b-ol 3-hydroxyimine
Chemical Formula: C20H33NO2
Molecular Weight: 319.5
CAS: NA
Q Qatio: 2.4
Anabolic #: 380/24
Androgenic #: 158/20
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: High
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
75-100mg/day standalone
50-75mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
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-3
-2
-1

0
1
2
3
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5

Muscle Gain

[][]
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0
1
2
3
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5

Strength Gain

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-5
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-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
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-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[][]
-5
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0
1
2
3
4
5

Hair Loss

[][][]
-5
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0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
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-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
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-2
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0
1
2
3
4
5

Lethargy

[]
-5
-4
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-1

0
1
2
3
4
5

Characteristics

Promestanolone is a 17aa pro-steroid which converts to the illegal anabolic steroid methyl-DHT (mestanolone).

There is no human clinical data on promestanolone, but it is most likely exerting its effects by converting to methyl-DHT. The acidic environment in the stomach would be responsible for converting the 3-hydroxyimine group to a 3-one — thus rapidly changing it to methyl DHT. Therefore results and side-effects would be considered to be very similar to methyl-DHT.

Although DHT can be deactivated in skeletal muscle tissue by 3b-HSD it is likely that this enzyme pathway can be overwhelmed if this compound is taken at a high enough dose. Methyl-DHT has some activity on the progestin receptor, but not to a high degree. It has moderate anabolic but high androgenic effects. It binds strongly to SHBG, therefore free testosterone and estrogen can be expected to rise by displacement from SHBG.

Since this is a 17aa compound, liver toxicity will be an issue with high doses or long term use. For this reason users should consider priming the liver with a liver supporting supplement before and during a Promestanolone cycle. Users will also experience minimal subcutaneous water retention since there is no conversion to estrogen. However, intracellular water and sodium retention will increase by inhibition of 11-beta hydroxylase and mineralocorticoid build up.

Users may also experience an increase in aggression and mood swings which is a common side effect of many steroids with high androgenic value. This makes this compound an excellent pre-lifting or pre-competition steroid.

Promestanolone should produce solid lean gains in muscle as a standalone. However for those looking to add additional bulk to their cycle, promestanolone would stack with with virtually any other non-17aa oral.

Common Clones:

D-Plex by Competetive Edge Labs (CEL)
The ONE by Applied Nutraceuticals


Related Discussion

The Official Promestanolone Thread
Posted by Eric

References

“Effect of 1-alkyl substitution on the biological action in a series of androstanes.”

Cekan Z, Pelc B.
Steroids. 1966 Aug;8(2):209-18.

“Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.”
Saartok T, Dahlberg E, Gustafsson JA.
Endocrinology. 1984 Jun;114(6):2100-6.

Transdermal Steroids – Expanded

If there is one topic that is misunderstood in the steroid community, it’s Transdermal Steroids (TS’s). The value of TS’s are under-estimated, and the science has been over looked by the vast majority. In this article, I intend to shed some light on TS’s and introduce a few new transdermal options that can offer benefits to athletes, bodybuilders and HRT patients alike.

As a developer of several transdermal products, and a counselor to a number of TRT patients; I’ve learned that a majority of men consider Androgel™ and Testim™ the only real viable topical hormones. This makes sense, being they are the most popular FDA approved testosterone gels currently available. However, there are more options to be considered. Steroid hormones such as nandrolone and boldenone offer useful advantages when delivered topically. Legal prohormones such as DHEA and pregnenolone can also offer great benefits when used topically (Found in Dermacrine). One benefit with all TS’s is their quick clearance from the body (generally less than 72hrs for most hormones). This is advantageous for PCT, when the quick clearance of hormones is desired (often a problem with long-acting injectable steroids which may take months to clear the system.)

Before we review some of the alternatives to testosterone gel, let’s take a quick look at some basic rules so we can have a better understanding of how we can manipulate the hormonal effects for our best interest.

Application site –

The site of application is one way to maximize the effectiveness of our topical hormones, while also altering the action the hormone has on the body. For instance, the skin on the front of the neck is thin and very vascular, making it ideal for systemic transdermal delivery. The skin on the shoulders and upper back – areas where you may have had acne as a teenager — are highly concentrated with steroidogenic enzymes such as 3b HSD and 17a HSD. These are the enzymes required to make hormonal conversions, such as DHEA > androstenediol > testosterone. On the flip side, the stomach area tends to carry a higher amount of the aromatase enzyme, especially if you’re prone to holding fat in the abdominal region. This would be an area to avoid applying testosterone gel, since the increased aromatase activity could increase the conversion to estrogen.

One area which can be advantageous to use for topical application is the scrotal skin. This area is extremely thin and easily penetrated by topical ingredients for systemic delivery. In fact, its absorption rate is about 4-5x more than anywhere else on the body. (1,2) This makes it the perfect spot for the delivery of topical ingredients, giving you more bank for the buck.

One thing to be aware of with scrotal applications is the higher conversion rate to DHT when applying testosterone to this area. There is heavier conversion to DHT because the scrotal skin carries a high concentration of the 5a-reductase enzyme. When the testosterone travels through the scrotal skin it interacts with the 5a-reductase enzyme and converts to DHT. This gives you a significant spike in DHT when you apply testosterone cream to your scrotum, which may or may not be a good thing. (see below for alternatives to testosterone and how to avoid the DHT)

An enlarged or irritated prostate is generally a symptom associated with high DHT. However, the DHT may not be entirely to blame. In fact, research has shown that topical DHT treatment can actually keep the prostate healthy and even reduce its size, as long as estrogen levels are also kept in control. (3,4) Plus, DHT is an antagonist of estrogen, so it’s going to help reduce gyno (male breasts) and water retention, while it also increase libido and erectile function. It could even be argued that DHT is more critical to a man’s well-being than testosterone.

Unfortunately, DHT can increase hair loss if you’re genetically prone to it, although this could be prevented if DHT levels are kept in range, bringing us to the next topic – the progesterone/DHT relationship. That’s right, progesterone can be healthy for a male too.

The word progesterone may sound frightening to some since it’s primarily known as a female hormone. However, it also offers health benefits for the male if used in very low and controlled amounts. You see, progesterone can naturally inhibit the conversion of testosterone to DHT thus helping to keep DHT in a healthy range (similar to finasteride albeit to a lesser degree). So how does this apply to real life?

Well, pregnenolone cream is legal and readily available in most counties, and as it passes the skin, pregnenolone readily interacts with the skins enzymes (3b HSD) and makes partial conversion to progesterone. (The reason for applying pregnenolone rather than strait progesterone is the added cognitive enhancements of pregnenolone.) In most cases, a 10-20mg application of pregnenolone cream would convert to sufficient amounts of progesterone to control DHT conversion from testosterone supplementation. (given via IM or topically)

If for whatever reason you don’t want to deal with combating DHT, or are extremely sensitive to its hair loss effects, you may want to consider using nandrolone or boldenone for topical application as alternatives to testosterone. If you’re lucky enough to have access to nandrolone or boldenone base powder, they are easily compounded into a topical and are perfect for transdermal delivery. These hormones are gentler on the hairline because they don’t convert to DHT. More specifically, when they interact with the 5a-reductase enzyme, they are converted to a less powerful 5a-reduced steroid, thus being ‘gentler’ than testosterone. Note: Nandrolone (Deca) can be a double edged sword given that it lacks a powerful 5a-reduced metabolite. It’s beneficial for preventing hair loss, but notorious for erectile dysfunction causes known as “Deca Dick”.

If you’re interested in staying legal and you don’t have access to AAS’s such as testosterone, nandrolone or boldenone, then DHEA is an excellent legal alternative, especially when used as a transdermal. When taken as a transdermal, DHEA is absorbed about 10x better than when taken orally. (5) Plus there is the additional benefit of increased metabolic conversion of hormones when they are taken through the skin. (6) As mentioned earlier, the shoulder and upper back skin have the highest concentration of enzymes required to make hormonal conversions (3b HSD & 17b HSD). Since DHEA is an immediate precursor to several anabolic hormones, the topical application of DHEA can cause a sharp rise in androstenediol, androstenedione and testosterone within a few hours of application. (These are the primary hormones that make Dermacrine so effective)

Remember, no matter what hormones you choose, be aware of moderation and balance.

 

References

1. Hypogonadal impotence treated by transdermal testosterone.
McClure RD et al. Urology 1991;37:224-8.

2. Testoderm TTS, Testoderm, and Testoderm with
adhesive [package inserts]. Mountain View, Calif: Alza Pharmaceuticals, 1998.

3. Percutaneous dihydrotestosterone (DHT) treatment. In: Nieschlag E, Behre HM, eds. Testosterone: action, deficiency substitution.
Schaison G, et al Berlin: Springer Verlag; 155-164. (1990)

4. Transdermal dihydrotestosterone and treatment of “andropause”.
de Lignieres B. Ann Med 1993;25: 235-41.

5. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat C Labrie, M Flamand, A Belanger, et al. Endocrinol., Sep 1996; 150: S107 – S118.

6. The in vitro metabolism of dehydroepiandrosterone in human skin.
I Faredin, et al. Med Acad Sci Hung, Jan 1967; 23(2): 169-79.

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