Cynostane

Diagram of molecule

Chemical Name(s):

2-cyano-17a-methyl-17b-hydroxy-androstan-3-one
2-cyano-17a-methyl-17b-hydroxy-androst-3-one (incorrect name)
Chemical Formula: C21H31NO2
Molecular Weight: 329
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
20-30mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

2-cyano-dromostolone is a 17aa molecule relatively new to the scene with very few reviews as of yet.

It has a cyano group attached to the 2 position. The chemical structure is the same as methyldrostanolone (Superdrol), except it has a CN group on the 2 position instead of a methyl group. It is a C-17aa steroid and it will be liver toxic. Although, due to the lack of the 4-ene on ring A and lack of 2-methylation, liver toxicity may be reduced relative to a di-methylated steroid such as Superdrol.

So far, feedback is very limited for this compound. However results would be expected to be fairly lean as this compound cannot convert to estrogen. Based on the chemical structure the anabolic potency would appear to be fairly potent with moderate androgenic potency.

At the time of this writing there was only one manufacturer to bring this product to the market and there seems to have been a nomenclature mistake on the labeling for this steroid. The chemical name contains the term “androst”, assuming that there is some sort of ene group on ring A. But there does not seem to be such mention of an ene group on ring A. Therefore, the term androst should be androstan. But if this is the case, the 2-cyano group needs to be stated as alpha or beta. This makes a big difference, since usually C2-alpha groups are significantly more effective than beta.

There are studies about other 2-cyano steroids such as 2-cyano-DHT and 2-cyano-progesterone. In separate studies, one done on dogs, it was seen that both of these 2-cyano steroids caused inhibition of 3b-HSD enzyme. This inhibition would cause severe adrenal suppression. This is a very unsafe inhibition. Whether it occurs in this cyano steroid is unknown, but users need to be aware of this possibility.

Common Clones:

Cynostane by Anabolic Innovation


Related Discussion

The Official Cynostane Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Methylstenbolone

Diagram of molecule

Chemical Name(s):
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one
Chemical Formula: C21H32O2
Molecular Weight: 316.5
CAS: NA
Q Qatio: 3.9
Anabolic #: 660
Androgenic #: 170
Oral Bioavailability: Estimated at 50%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
5-20mg/day standalone
1-5mg/day when stacked
Average Cycle Length: 2-4 weeks

 

Stimulator
Inhibitor

 

 
-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

 

Characteristics

Although this compound cannot convert to estrogen, it will bind strongly to SHBG, thus increasing freely circulating estrogen (and testosterone). While there is a lack of anecdotal feedback from this compound to tell the real world effect this compound may have on causing gyno, experience with related compounds tell us gyno symptoms may occur.

Users should be very careful with methylstenbolone and start out with a very low dose. This compound will likely produce a rapid increase in intracellular water retention by inhibiting 11-beta hydroxylase and building up levels of mineralcorticoids that will encourage sodium and water retention.

Gains upwards of 20-25lbs in 4 weeks are probably possible with this compound. However the liver toxicity issues would likely be the first reason why someone wouldn’t be able to make incredible gains from this compound. For this reason it would be extremely important to pre-condition the liver with a liver protecting supplement prior to cycling this compound, while continuing use throughout the cycle and during PCT.

The strength increases from this compound will likely encourage weight lifting heavier than tendons and joints are prepared to lift. It is recommended to be cautious of this and to naturally build up strength levels prior to cycling this steroid.

Using a low dose of methylstenbolone with a moderate dose of a non-methylated compound would be an acceptable way to try to limit the side-effects from this compound, although caution would still need to be taken for liver health no matter what dose is used.

Because of the strength and weight gain this compound would offer it would likely be best used as part of a bulking cycle.

Availability: 

UltraDrol by Antaeus Labs

Related Discussion

The Official Methylstenbolone Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

1,4,6 Androstatriene-dione (ATD)

Diagram of molecule

Chemical Name(s):

Androsta-1,4,6-triene-3,17-dione
1,4,6-androstatriene-3,17-dione
Chemical Formula: C19H22O2
Molecular Weight: 282
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: 2 days
Legal Status (US): Not listed as a controlled substance
Average Dose: 25-100mg/day
Average Cycle Length: 4-8 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

ATD is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

ATD is used for its aromatase inhibiting and testosterone boosting effect. Its effectiveness at lowering estrogen appears to be stronger than 6-oxo. It converts to 1,4,6-testosterone, which would also be expected to cause falsely high readings for a testosterone analysis.

The 1,4,6-testosterone metabolite of ATD can also bind to the androgen receptor (AR) and induce androgenic (or possibly anti-androgenic) effects similar to what is seen from 6-oxo. This would be expected since 1,4,6-testosterone has about one third the binding affinity for the AR, therefore it may interefere with the anabolic or androgenic action of hormones which bind the androgen receptor.

ATD would also be expected to interfere with production of natural testosterone by acting upon the hypothalamus pituitary testicular axis (HPTA), therefore this compound should not be used during post cycle therapy (PCT), however it could successfully be used during a cycle to help keep estrogen in control. Anecdotal reports and animal studies have also shown ATD inhibits libido and general sexual potency.

Common Clones:

Arom-X by Advanced Muscle Science (AMS)
AIFM by Anafit
ATD MAX by Anabolic Formulations
ATD-JET by Molecular Developments
Reversitol by IForce


Related Discussion

The Official 1,4,6 Androstatriene-dione (ATD) Thread
Posted by Eric

References

Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.

Exp Brain Res. 1986;64(3):407-10.
Slama A, Gogan F, Sarrieau A, Vial M, Rostene W, Kordon C.

Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
ME Kaplan and MY McGinnis
Horm Behav, Mar 1989; 23(1): 10-26.

Anabolic Pharmacology
Seth Roberts (2009)

1-Androsterone

Diagram of molecule

Chemical Name(s):

1-androsten-3b-ol-17-one
1-Dehydroepiandrosterone
Chemical Formula: C19H28O2
Molecular Weight: NA
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 8%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
200-300mg/day Transdermally
400-600mg/day standalone (oral)
200-400mg/day when stacking (oral)
Average Cycle Length: 4-6 weeks

Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

1- Androsteronetm (1-DHEA) is a non-methylated (non 17aa) pro-steroid that must convert to 1-androstenediol (1-AD), 1-androstenedione (original 1-AD) and/or 1-testosterone to be active. The double bond in the 1st position seems to slightly enhance its ability to resist excretion by the liver.

1-Androsterone occurs naturally in the body, and is a naturally occurring metabolite of DHEA. (2) The 17b-HSD enzyme converts 1-Androsterone to 1-Androstenediol, and the 3b-HSD converts it to 1-Androstenedione. Both of these 1-AD metabolites can then be converted to 1-Testosterone. Although the 1-AD metabolites are known to have some anabolic and androgenic effects on their own, 1-Testosterone is probably where most of the effects come from with this steroid.

There is no conversion to estrogen so users will not experience bloat with this compound, nor will it have a dramatic effect on blood pressure. However one unique side effect that users have reported with this compound is a feeling of lethargy. (It appears that stacking 1-Androsterone with a nuero-active hormone such as DHEA can help reverse this effect)

1-Androsterone (and primarily its metabolites) have relatively potent androgenic effects, therefore gyno is almost never an issue. However, because of the androgenic potency, this compound could pose a mild hair loss risk for those prone to MPB. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Results from this compound generally take a couple weeks to be realized. Moderate gains of lean muscle mass and strength can be expected, but users should not expect rapid increases in size or weight with this compound since extra-cellular and intra-cellular water retention are very minimal. This makes the gains from this steroid fairly easy to maintain post cycle.

1-Androsterone will stack well with almost any compound. For more dramatic gains in size and strength it is recommended to stack this compound with an aromatizing steroid or possibly one of the progestational compounds listed elsewhere.

Common Clones:

1-T by Primordial Performance
1-Androsterone by Advanced Muscle Science (AMS)

Related Discussion

The Official 1-Androsterone Thread
Posted by Eric

References

1. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties.

A Friedel, et al.
Toxicol Lett, Aug 2006; 165(2): 149-55.

2. “Metabolism of 1-Dehydroandrostanes in Man”
Galletti and Gardi, et al.
J Steroid Biochem, 3 (1972), 933-936

Halodrol

Diagram of molecule

Chemical Name(s):
4-chloro-17a-methyl-androst-1,4-diene-3b,17b-diol
Chemical Formula: C20H29C1O2
Molecular Weight: 337
CAS: NA
Q Qatio: 2.6
Anabolic #: 74
Androgenic #: 28
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~16 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
100-150mg/day standalone
50-100mg/day when stacking
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[][][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Halodrol is a 17aa steroid that converts to the steroid oral Turinabol after interaction with 3b-HSD at an estimated rate of about 5%.

Because of this low conversion, doses must be higher than other 17aa pro-steroids. However, it is suspected that Halodrol has decent potency without conversion as good results are seen despite the relatively low conversion to Turinabol. Based on Vida’s data Halodrol appears to be about as potent as testosterone, and significantly less androgenic.

Because of the 4-chloro group, halodrol has no progestational effects, it cannot interact with the aromatase enzyme, and it produces inactive 4-chloro-DHT metabolites. This makes androgenic side-effects such as hair loss, high blood pressure, acne and prostate enlargement less likely. Anecdotal reports would also have us believe that side-effects with this compound are fairly mild.

Although caution would still need to be had, the low androgenic value of this compound would also make it one of the more appropriate anabolic steroids for women wishing increase lean mass yet avoid a deeper voice, increased hair growth, acne and clitoral growth. (Oral Turinabol was actually the preferred steroid for Olympic female athletes in East Germany)

The lack of androgenic potency might be expected to create problems with gyno, however the low SHBG binding affinity has minimal interference with SHBG levels and/or freely circuiting estrogen and testosterone. It does not appear that halodrol has a significant gyno risk.

Because halodrol must be used at such a high dose to see noticeable effects, liver toxicity may become an issue. Therefore it is recommended to use a liver protecting supplement before and during halodrol cycles.

Gains from Halodrol generally take a few weeks to notice, but users can expect solid increases in strength, lean muscle mass, improved vascularity and minimal water retention. This allows some of the gains to be kept after the cycle if good diet and training are continued. Quick dramatic gains in size and strength are not generally noticed with Halodrol.

It is used successfully as a standalone, but would be expected to stack well with most other steroids, except 17aa oral due to liver toxicity concerns.

Common Clones:

Halo-MASS by Anabolic Formulations
HD-1 by Performance Design
H-Drol by Competitive Edge Labs (CEL)
Halovar by Purus Labs
Hemadrol by Engineered Sports Technology (EST)
Halodrol-50 by Gaspari Nutrition
Oral Turinadrol by Juggernaut Nutrition
Super Halo by Black China Labs
H-Drol by Nutracoastal
Helladrol by Mrsupps


Related Discussion

The Official Halodrol Thread
Posted by Eric

References

“Hepatotoxicity Associated With Dietary Supplements Containing Anabolic Steroids”

Michel I. Kafrouni, Robert A. Anders and Sumita Verma
Clinical Gastroenterology and Hepatology; Volume 5, Issue 7, July 2007, Pages 809-812

4-DHEA

Diagram of molecule

Chemical Name(s):

1-androsten-3b-ol-17-one
4-Dehydroepiandrosterone
Chemical Formula: C19H28O2
Molecular Weight: 288
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 4%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: NA
Legal Status (US): Not listed as a controlled substance
Average Dose:
500-1000mg/day standalone
200-500mg/day when stacked
Average Cycle Length: 4-6 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[][]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

4-DHEA is a naturally occurring non-methylated (non-17aa) pro-steroid.

4-DHEA, like DHEA, requires a 2 step conversion process involving 3b-HSD and 17b-HSD to convert it to Androstenedione/androstenediol, and then testosterone. What makes 4-DHEA slightly different from DHEA is a double bond in the 4th position rather than the 5th. This makes 4-DHEA less estrogenic by not acting directly upon the estrogen receptor like DHEA has been found to do.

Although 4-DHEA can aromatize to estrogen it is probably not enough to cause high estrogen related side-effects.

Overall results will be similar to or the original 4-AD banned back in 2004. Higher doses of this compound will produce fairly lean gains in muscle mass, with moderate improvements in strength. This product may produce some bloat from the estrogen conversion, which could be countered by administering an aromatase inhibitor, but this will largely defeat the purpose of using this compound to begin with.

Since this compound is naturally occurring and non-methylated overall side-effects will be fairly mild. However, high doses may also lead to oily skin, acne and increased blood pressure. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.

Because this compound can convert to testosterone it can also convert to DHT and other 5a-reduced metabolites. This can serve as a good stack with progestational or relatively non-androgenic compounds that may create problems with libido or gyno because of lacking androgenic potency.

Although this compound is relatively safe and moderately effective, its high cost has probably been the reason for its lack of popularity.

Common Clones:

4-AD UTT by Advanced Muscle Science (AMS)


Related Discussion

The Official 4-DHEA Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

Exemestane (Aromasin)

Diagram of molecule

Chemical Name(s):

6-methyleneandrosta-1,4-dien-3,17-dione
Chemical Formula: C20H24O2
Molecular Weight: 296
CAS: NA
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 15%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: 27 hours
Legal Status (US): Prescription only
Average Dose: 10-25mg/day
Average Cycle Length: 4-8 weeks
Stimulator
Inhibitor

-5
-4
-3
-2
-1

0
1
2
3
4
5

Muscle Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Strength Gain

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Fat Gain (negative indicates fat loss)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Water Retention (extra-cellular bloat)

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Aggression

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Libido

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Acne

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Hair Loss

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Prostate Enlargement

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Liver Toxicity

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Lethargy

[]
-5
-4
-3
-2
-1

0
1
2
3
4
5

Characteristics

Exemestane is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.

Exemestane is one of the most potent and expensive steroidal aromatase inhibitors currently available on the market. It is available by prescription only. The estrogen inhibition rate for exemestane varies from 85% of estradiol to 95% for estrone.

Exemestane is looked highly upon due to the fact it can be just as effective as Letrozole or Arimidex without causing such a rapid rebound of estrogen, which is a typical problem of non-suicidal aromatase inhibitors.

Exemstane is rarely dosed beyond 25mg/day as this appears to be a high enough dose to suppress estrogen by a significant amount. It can reach maximum estrogen suppression in as little as 7 days. Since it increases testosterone levels, some users may experience androgenic effects.


Related Discussion

The Official Exemestane (Aromasin) Thread
Posted by Eric

References

Anabolic Pharmacology
Seth Roberts (2009)

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