Insulin Sensitivity Affects Testosterone Levels in the Body

Insulin sensitivity affects testosterone levels in the bodyJanuary 7th, 2010 – Research has shown that people with type II diabetes and metabolic syndrome (i.e. insulin resistance) have significantly lower testosterone levels than regular men. (1,2) Insulin resistance is basically a condition where the insulin created by the body is insufficient to drive nutrients into the muscle and fat cells. This stems from having chronically elevated blood insulin levels.

Under constant stimulation from insulin, cellís become less sensitive to its effects, requiring more and more insulin to get nutrients into the cells. Therefore, anything which drives up blood sugar – like sugar, rice, pasta, beer, carbs of all kinds – and thus insulin levels can lead to a reduction in insulin sensitivity. Reduced insulin sensitivity equals lower testosterone levels.

References –

1. The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance.

Traish AM, Saad F, Guay A.

J Androl 2009 Jan-Feb;30(1):23-32

2. Low testosterone levels are common and associated with insulin resistance in men with diabetes.

Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, Macisaac RJ, Clarke S, Zajac JD, Jerums G.

J Clin Endocrinol Metab. 2008 May;93(5):1834-40

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Pomegranate Juice Increases Male Fertility

Pomegranate Juice Increases Male FertilityJan 7th, 2010 – Pomegranate juice is rich with vitamin C and polyphenolic compounds such as anthocyanins, punicalagin, ellagic and gallic acid. It is well known that these nutrients are powerful anti-oxidants which suppress and scavenge damaging free radicals – which now appear to play an important role in enhancing the health and mobility of sperm. (1)

A recent study with male rats demonstrated that 7 weeks of pomegranate consumption increased spermatogenic cell density, epididymal sperm concentration, sperm motility and decreased abnormal sperm rate, and serum testosterone levels – all important parameters of male fertility.

Sperm are especially sensitive to oxidative damage from free radicals because of the unsaturated fatty acid composition in their outer membrane. When the sperm’s membrane becomes damaged by free radicals it decreases its viability. In extreme cases, excessive free radical damage can completely inhibit spermatogenesis. (2)

Sperm are always going to generate free radicals through their natural metabolism, so it’s important to supplement the diet with potent anti-oxidants to allow the body to properly protect itself.

-Eric Potratz

Founder & President


References –

1. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in the male rat.

Gaffari Turk, et al.

Clinical Nutrition (2008) 27, 289.297

2. The impact of oxidants on sperm functions.

Henkel R, et al.

Andrologia 2005; 37:205-6

Lipoprotein Lipase Important for Fat Burning

Lipoprotein lipase important for fat burningJanuary 7th, 2010 – Lipoprotein lipase (LPL) is an enzyme that breaks apart fat (triglycerides) into their fatty acid components for transport and use inside cells.

An increase in lipoprotein lipase activity means an increase in the flow of fatty acids into the cell.  An increase in LPL activity in muscle cells means they will use more fat and less sugar for energy, which is a good thing if you are trying to stay lean.  An increase in LPL activity in fat cells, however, will mean increased fat stores.  There are many factors involved in the regulation of LPL activity, but two big contributors are the hormones insulin and testosterone.

Insulin increases LPL activity in fat cells, while decreasing LPL activity in muscle cells.  (1) Anything that drives up insulin (mainly dietary carbohydrates) will increase the flow of fatty acids into fat cells for storage and cause muscle cells to burn sugar instead of fat.

Testosterone also has a regulatory effect on LPL activity in muscle. Lipoprotein lipase activity in the fat cells of the abdominal region is greater in men than in women, and reduced testosterone levels only increases activity.  Keeping testosterone levels high, however, works to reduce LPL activity in the male abdominal fat cells thus discouraging fat storage in this area. (2)

References –

1. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men.

Fried SK, Russell CD, Grauso NL, Brolin RE.

J Clin Invest. 1993 Nov;92(5):2191-8

2. Good Calories Bad Calories

Gary Taubes

Alfred A Knopf 2007 Pages 397-399

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